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Tbio
CD1C
T-cell surface glycoprotein CD1c

Protein Summary
Description
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368170
  • ENSP00000357152
  • ENSG00000158481

Symbol
  • R7
  • CD1
  • CD1A
  • BDCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.63
metabolite
0.62
cellular component
0.58
biological term
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1126.97   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 607   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1126.97   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 607   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
10
neurofilament light chain measurement
1
1
0
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
10
neurofilament light chain measurement
0
1
2.6
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD1c molecule
VGNC:5007
457419
Macaque
CD1c molecule
717148
Dog
CD1c molecule
VGNC:53115
488609
Horse
CD1c molecule
100056353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD1c molecule
Macaque
CD1c molecule
Dog
CD1c molecule
Horse
CD1c molecule
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29017-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (185)
1 – 10 of 185
B2M
Tbio
Novelty:  0.00011248
Score:  0.994
Data Source:  Reactome,STRINGDB
CD3E
Tclin
Novelty:  0.0053855
Score:  0.943
Data Source:  Reactome,STRINGDB
CD3D
Tclin
Novelty:  0.00510314
Score:  0.931
Data Source:  Reactome,STRINGDB
CD3G
Tclin
Novelty:  0.00466154
Score:  0.904
Data Source:  Reactome,STRINGDB
CD83
Tbio
Novelty:  0.00138653
Score:  0.896
Data Source:  STRINGDB
CD86
Tclin
Novelty:  0.00029965
Score:  0.892
Data Source:  STRINGDB
CD207
Tbio
Novelty:  0.00313729
Score:  0.875
Data Source:  STRINGDB
CSF2
Tbio
Novelty:  0.00010437
Score:  0.859
Data Source:  STRINGDB
CD68
Tbio
Novelty:  0.00017859
Score:  0.844
Data Source:  STRINGDB
CLEC4C
Tbio
Novelty:  0.00845053
Score:  0.831
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1126.97

PubMed score by year
PubTator Score  963.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer