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Tbio
CD1B
T-cell surface glycoprotein CD1b

Protein Summary
Description
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368168
  • ENSP00000357150
  • ENSG00000158485

Symbol
  • R1
  • CD1
  • CD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
metabolite
0.62
biological term
0.54
cellular component
0.5
gene perturbation
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.59   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 631   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.59   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
17.6
reticulocyte measurement
1
1
1
13.1
HbA1c measurement
1
1
1
10
neurofilament light chain measurement
1
1
0
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
17.6
reticulocyte measurement
1
13.1
HbA1c measurement
1
10
neurofilament light chain measurement
0
1
2.6
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD1b molecule
VGNC:5006
457420
Macaque
CD1b molecule
718955
Dog
CD1b molecule
VGNC:53114
100174779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD1b molecule
Macaque
CD1b molecule
Dog
CD1b molecule
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29016-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (155)
1 – 10 of 155
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.999930337
p_ni:  0.000069613
p_wrong:  5e-8
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999870454
p_ni:  0.000123494
p_wrong:  0.000006052
Score:  0.247
Data Source:  BioPlex,STRINGDB
NRSN2
Tbio
Novelty:  0.1812093
p_int:  0.999773873
p_ni:  0.000183493
p_wrong:  0.000042634
Score:  0.179
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.999436638
p_ni:  0.000563361
p_wrong:  1e-9
Data Source:  BioPlex
LNPK
Tbio
Novelty:  0.07736762
p_int:  0.997375461
p_ni:  0.002624502
p_wrong:  3.7e-8
Data Source:  BioPlex
BTN2A2
Tdark
Novelty:  0.46565474
p_int:  0.996320635
p_ni:  0.003679365
Data Source:  BioPlex
PCYOX1L
Tdark
Family:  Enzyme
Novelty:  1.25398886
p_int:  0.994270414
p_ni:  0.005637062
p_wrong:  0.000092524
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.993094237
p_ni:  0.006901975
p_wrong:  0.000003788
Data Source:  BioPlex
CNTNAP3B
Tdark
Novelty:  0.25889644
p_int:  0.991812053
p_ni:  0.008098233
p_wrong:  0.000089715
Data Source:  BioPlex
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.987616148
p_ni:  0.012370991
p_wrong:  0.000012861
Data Source:  BioPlex
Publication Statistics
PubMed Score  965.59

PubMed score by year
PubTator Score  515.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer