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Tclin
TNFRSF8
Tumor necrosis factor receptor superfamily member 8

Protein Summary
Description
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263932
  • ENSP00000263932
  • ENSG00000120949
  • ENST00000413146
  • ENSP00000398337
  • ENST00000417814
  • ENSP00000390650

Symbol
  • CD30
  • D1S166E
  • CD30
  • Ki-1
  • D1S166E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.94
gene perturbation
0.74
transcription factor
0.74
PubMedID
0.71
cell type or tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3399.25   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 2061   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3399.25   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 2061   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
2
2
60.5
2
1
0
1.2
48
1
1
0
1.1
45.9
Eczema
1
1
0
1.1
45.9
eosinophil count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
60.5
0
1.2
48
0
1.1
45.9
Eczema
0
1.1
45.9
eosinophil count
1
44.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 8
VGNC:7012
457960
Macaque
TNF receptor superfamily member 8
722773
Mouse
MGI:99908
21941
Rat
RGD:3879
25069
Dog
TNF receptor superfamily member 8
VGNC:47667
487438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 8
Macaque
TNF receptor superfamily member 8
Mouse
Rat
Dog
TNF receptor superfamily member 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28908-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (143)
1 – 10 of 143
NAA25
Tbio
Family: Enzyme
Novelty: 0.05422122
p_int: 0.999999168
p_ni: 8.32e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
CCDC112
Tbio
Novelty: 0.04210064
p_int: 0.999998149
p_ni: 0.000001851
Score: 0.188
Data Source: BioPlex,STRINGDB
NAA20
Tbio
Family: Enzyme
Novelty: 0.07814789
p_int: 0.999997825
p_ni: 2e-8
p_wrong: 0.000002155
Score: 0.282
Data Source: BioPlex,STRINGDB
CEP57
Tbio
Novelty: 0.05529464
p_int: 0.999995282
p_ni: 0.000004645
p_wrong: 7.3e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
p_int: 0.99998856
p_ni: 0.00001144
Score: 0.637
Data Source: BioPlex,STRINGDB
DPY19L1
Tdark
Family: Enzyme
Novelty: 0.34765717
p_int: 0.999928798
p_ni: 0.000071202
Data Source: BioPlex
DAPK3
Tchem
Family: Kinase
Novelty: 0.01551494
p_int: 0.999897088
p_ni: 0.000102904
p_wrong: 8e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.999720438
p_ni: 0.000279562
Score: 0.707
Data Source: BioPlex,STRINGDB
SPATS2
Tdark
Novelty: 0.20594325
p_int: 0.999680429
p_ni: 0.000319483
p_wrong: 8.8e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
BLOC1S1
Tbio
Novelty: 0.02921036
p_int: 0.999577606
p_ni: 0.000390856
p_wrong: 0.000031539
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3399.25

PubMed score by year
PubTator Score  2250.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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