Tclin TNFRSF8 Tumor necrosis factor receptor superfamily member 8

Protein Summary

Description

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28908
• B1AN79
• B9EGD9
• D3YTD8
• Q6P4D9

Gene Name

• TNFRSF8

Ensembl ID

• ENST00000263932
• ENSP00000263932
• ENSG00000120949
• ENST00000413146
• ENSP00000398337
• ENST00000417814
• ENSP00000390650

Symbol

• CD30
• D1S166E
• CD30
• Ki-1
• D1S166E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.94
gene perturbation	0.74
transcription factor	0.74
PubMedID	0.71
cell type or tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3788.1   (req: < 5)

Gene RIFs: 192   (req: <= 3)

Antibodies: 2061   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3788.1   (req: >= 5)

Gene RIFs: 192   (req: > 3)

Antibodies: 2061   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1