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Tclin
HSD11B1
Corticosteroid 11-beta-dehydrogenase isozyme 1

Protein Summary
Description
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367027
  • ENSP00000355994
  • ENSG00000117594
  • ENST00000367028
  • ENSP00000355995

Symbol
  • HSD11
  • HSD11L
  • SDR26C1
  • HDL
  • 11-DH
  • HSD11
  • HSD11B
  • HSD11L
  • CORTRD2
  • SDR26C1
  • 11-beta-HSD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
biological term
0.95
disease perturbation
0.87
chemical
0.81
drug
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1072.35   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1072.35   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2721
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (2721)
CHEMBL128729
Rendered image for CHEMBL128729
CHEMBL522964
Rendered image for CHEMBL522964
CHEMBL373257
Rendered image for CHEMBL373257
CHEMBL341324
Rendered image for CHEMBL341324
CHEMBL3127882,CHEMBL2179014
Rendered image for CHEMBL3127882,CHEMBL2179014
CHEMBL2158890
Rendered image for CHEMBL2158890
CHEMBL1829781
Rendered image for CHEMBL1829781
CHEMBL1829773
Rendered image for CHEMBL1829773
CHEMBL4100755
Rendered image for CHEMBL4100755
Protein-Protein Interactions (94)
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
p_int:  0.989522025
p_ni:  0.010477975
Score:  0.274
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.935352937
p_ni:  0.064647033
p_wrong:  2.9e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
TMX4
Tdark
Novelty:  0.2628295
p_int:  0.915927889
p_ni:  0.084072071
p_wrong:  4e-8
Score:  0.232
Data Source:  BioPlex,STRINGDB
TMBIM6
Tbio
Novelty:  0.00151958
p_int:  0.84386517
p_ni:  0.155966216
p_wrong:  0.000168614
Score:  0.204
Data Source:  BioPlex,STRINGDB
HSD3B1
Tchem
Family:  Enzyme
Novelty:  0.0019271
Score:  0.963
Data Source:  STRINGDB
CYP11B1
Tclin
Family:  Enzyme
Novelty:  0.00195229
Score:  0.954
Data Source:  STRINGDB
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
Score:  0.95
Data Source:  STRINGDB
CYP11B2
Tchem
Novelty:  0.00128614
Score:  0.946
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.945
Data Source:  STRINGDB
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Glucocorticoid biosynthesis (R-HSA-194002)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucocorticoid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Glucocorticoid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
6
0
1.7
97.4
Cleft palate
3
4
0
1.6
92.5
Oral cleft
2
3
1
1.6
86.5
mean corpuscular hemoglobin concentration
1
1
1
72.6
mean corpuscular volume
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
97.4
Cleft palate
0
1.6
92.5
Oral cleft
1
1.6
86.5
mean corpuscular hemoglobin concentration
1
72.6
mean corpuscular volume
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 11-beta dehydrogenase 1
VGNC:11453
457698
Mouse
MGI:103562
15483
Rat
RGD:2834
25116
Dog
hydroxysteroid 11-beta dehydrogenase 1
VGNC:41797
449023
Horse
hydroxysteroid 11-beta dehydrogenase 1
VGNC:18880
100056429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 11-beta dehydrogenase 1
Mouse
Rat
Dog
hydroxysteroid 11-beta dehydrogenase 1
Horse
hydroxysteroid 11-beta dehydrogenase 1
Publication Statistics
PubMed Score 1072.35
PubMed score by year
PubTator Score 349.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title