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Tchem
PTPRM
Receptor-type tyrosine-protein phosphatase mu

Protein Summary
Description
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332175
  • ENSP00000331418
  • ENSG00000173482
  • ENST00000580170
  • ENSP00000463325

Symbol
  • PTPRL1
  • RPTPM
  • RPTPU
  • PTPRL1
  • hR-PTPu
  • R-PTP-MU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
PubMedID
0.96
disease perturbation
0.95
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.32   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.32   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2396718
Rendered image for CHEMBL2396718
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
excessive daytime sleepiness measurement
1
1
1
21.5
sitting height ratio
1
1
1
14.2
risk-taking behaviour
1
1
1
14.2
body height
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
excessive daytime sleepiness measurement
1
21.5
sitting height ratio
1
14.2
risk-taking behaviour
1
14.2
body height
1
4.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type M
VGNC:9916
455298
Macaque
protein tyrosine phosphatase, receptor type M
722426
Mouse
MGI:102694
19274
Rat
RGD:620776
29616
Dog
protein tyrosine phosphatase, receptor type M
VGNC:45192
480203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type M
Macaque
protein tyrosine phosphatase, receptor type M
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type M
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28827-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (45)
1 – 10 of 45
PIP5K1C
Tchem
Family:  Kinase
Novelty:  0.0323077
Score:  0.906
Data Source:  STRINGDB
NECTIN3
Tbio
Novelty:  0.01288113
Score:  0.906
Data Source:  STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.9
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.897
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.883
Data Source:  STRINGDB
CDKL5
Tchem
Family:  Kinase
Novelty:  0.00444062
Score:  0.711
Data Source:  STRINGDB
NAV3
Tbio
Novelty:  0.0311655
Score:  0.651
Data Source:  STRINGDB
PAWR
Tbio
Novelty:  0.01108457
Score:  0.634
Data Source:  STRINGDB
E2F7
Tbio
Family:  TF
Novelty:  0.00797578
Score:  0.633
Data Source:  STRINGDB
RALGPS2
Tdark
Novelty:  0.32828463
Score:  0.607
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.32

PubMed score by year
PubTator Score  24.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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