Tbio RBL1 Retinoblastoma-like protein 1

Protein Summary

Description

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28749
• A8K2W5
• Q4VXA0
• Q8N5K6
• Q9H1L5
• Q9H1M1

Gene Name

• RBL1

Ensembl ID

• ENST00000344359
• ENSP00000343646
• ENSG00000080839
• ENST00000373664
• ENSP00000362768

Symbol

• PRB1
• p107
• CP107

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.97
viral protein	0.93
protein domain	0.92
histone modification site profile	0.89
virus	0.89

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Retinoblastoma-like Protein 1

Protein / Nucleic Acid Binding / Retinoblastoma-like Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Retinoblastoma-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.09   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.09   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (165)

Explore Interacting Targets

1 – 10 of 165

• See Interactions on String-DB

CCNA2

Tchem

Novelty:  0.00049887

p_int:  0.999999984

p_ni:  1.6e-8

Score:  0.995

Data Source:  BioPlex,STRINGDB

CITED1

Tbio

Novelty:  0.01956689

p_int:  0.999999972

p_ni:  2.8e-8

Score:  0.381

Data Source:  BioPlex,STRINGDB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

p_int:  0.99999967

p_ni:  1e-9

p_wrong:  3.29e-7

Score:  0.992

Data Source:  BioPlex,Reactome,STRINGDB

TXNDC11

Tbio

Novelty:  0.07135045

p_int:  0.999995441

p_ni:  0.000004559

Score:  0.773

Data Source:  BioPlex,STRINGDB

CTBP1

Tbio

Novelty:  0.00243818

p_int:  0.999972056

p_ni:  0.000027678

p_wrong:  2.66e-7

Score:  0.403

Data Source:  BioPlex,STRINGDB

C3orf62

Tdark

Novelty:  1.85670012

p_int:  0.999967342

p_ni:  0.000032658

Score:  0.295

Data Source:  BioPlex,STRINGDB

E2F5

Tbio

Family:  TF

Novelty:  0.00674159

Score:  0.999

Data Source:  Reactome,STRINGDB

E2F4

Tbio

Family:  TF

Novelty:  0.00317412

Score:  0.999

Data Source:  Reactome,STRINGDB

TFDP1

Tbio

Family:  TF

Novelty:  0.02026858

Score:  0.998

Data Source:  Reactome,STRINGDB

LIN52

Tbio

Novelty:  0.08105335

Score:  0.995

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (36)

Reactome (21)

KEGG (5)

PathwayCommons (6)

WikiPathways (4)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cyclin D associated events in G1	45 targets	R-HSA-69231
Reactome	G0 and Early G1	27 targets	R-HSA-1538133
Reactome	G1 Phase	45 targets	R-HSA-69236

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cyclin D associated events in G1	45 targets	R-HSA-69231
G0 and Early G1	27 targets	R-HSA-1538133
G1 Phase	45 targets	R-HSA-69236

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (4)

Components (3)

Processes (12)

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1 – 4 of 4

GO Term	Evidence	Assigned by
promoter-specific chromatin binding	Inferred from Direct Assay (IDA)	MGI
transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB
RNA polymerase II activating transcription factor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA polymerase II regulatory region DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (8)

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1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4	4	5		95.1
suntan	EFO_0004279	1	2	2		93.4
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		73
mean corpuscular volume	EFO_0004526	1	1	1		64
mean reticulocyte volume	EFO_0010701	1	1	1		59.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	5		95.1
suntan	EFO_0004279	2		93.4
mean corpuscular hemoglobin concentration	EFO_0004528	1		73
mean corpuscular volume	EFO_0004526	1		64
mean reticulocyte volume	EFO_0010701	1		59.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Chromatin regulator
Complete proteome
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
body height
lymphocyte count
lymphocyte percentage of leukocytes
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
red blood cell distribution width
suntan

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RB transcriptional corepressor like 1	VGNC:10511	735916
Macaque	RB transcriptional corepressor like 1		701650
Mouse	RB transcriptional corepressor like 1	MGI:103300	19650
Rat	RB transcriptional corepressor like 1	RGD:1595511	680111
Dog	RB transcriptional corepressor like 1	VGNC:45402	477221

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RB transcriptional corepressor like 1
Macaque	RB transcriptional corepressor like 1
Mouse	RB transcriptional corepressor like 1
Rat	RB transcriptional corepressor like 1
Dog	RB transcriptional corepressor like 1

Publication Statistics

PubMed Score 402.09

PubMed score by year

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PubTator Score 233.87

PubTator score by year

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Related Publications

Text Mined References (96)

GeneRif Annotations (29)

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PMID	Year	Title