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Tbio
RBL1
Retinoblastoma-like protein 1

Protein Summary
Description
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344359
  • ENSP00000343646
  • ENSG00000080839
  • ENST00000373664
  • ENSP00000362768

Symbol
  • PRB1
  • p107
  • CP107
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
viral protein
0.93
protein domain
0.92
histone modification site profile
0.89
virus
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.46   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.46   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
74.5
red blood cell distribution width
2
2
2
60.8
body height
1
1
1
43.2
mean corpuscular volume
1
1
1
34
mean reticulocyte volume
1
1
1
30.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
74.5
red blood cell distribution width
2
60.8
body height
1
43.2
mean corpuscular volume
1
34
mean reticulocyte volume
1
30.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB transcriptional corepressor like 1
VGNC:10511
735916
Macaque
RB transcriptional corepressor like 1
701650
Mouse
MGI:103300
19650
Rat
RGD:1595511
680111
Dog
RB transcriptional corepressor like 1
VGNC:45402
477221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB transcriptional corepressor like 1
Macaque
RB transcriptional corepressor like 1
Mouse
Rat
Dog
RB transcriptional corepressor like 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin D associated events in G1
Reactome
G0 and Early G1
Reactome
G1 Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin D associated events in G1
G0 and Early G1
G1 Phase
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (165)
1 – 10 of 165
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999999984
p_ni: 1.6e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.999999972
p_ni: 2.8e-8
Score: 0.381
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.99999967
p_ni: 1e-9
p_wrong: 3.29e-7
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
TXNDC11
Tbio
Novelty: 0.07135045
p_int: 0.999995441
p_ni: 0.000004559
Score: 0.773
Data Source: BioPlex,STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999972056
p_ni: 0.000027678
p_wrong: 2.66e-7
Score: 0.403
Data Source: BioPlex,STRINGDB
C3orf62
Tdark
Novelty: 1.85670012
p_int: 0.999967342
p_ni: 0.000032658
Score: 0.295
Data Source: BioPlex,STRINGDB
E2F5
Tbio
Family: TF
Novelty: 0.00674159
Score: 0.999
Data Source: Reactome,STRINGDB
E2F4
Tbio
Family: TF
Novelty: 0.00317412
Score: 0.999
Data Source: Reactome,STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02026858
Score: 0.998
Data Source: Reactome,STRINGDB
LIN52
Tbio
Novelty: 0.08105335
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  399.46

PubMed score by year
PubTator Score  233.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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