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Tchem
ERCC5
DNA repair protein complementing XP-G cells

Protein Summary
Description
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, whic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355739
  • ENSP00000347978
  • ENSG00000134899
  • ENST00000375954
  • ENSP00000365121
  • ENST00000535557
  • ENSP00000442117

Symbol
  • ERCM2
  • XPG
  • XPGC
  • XPG
  • UVDR
  • XPGC
  • COFS3
  • ERCM2
  • ERCC5-201
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
transcription factor binding site profile
0.93
protein domain
0.92
disease perturbation
0.9
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.06   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.06   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (32)
1 – 10 of 32
CHEMBL361962
Rendered image for CHEMBL361962
CHEMBL361011
Rendered image for CHEMBL361011
CHEMBL359533
Rendered image for CHEMBL359533
CHEMBL183133
Rendered image for CHEMBL183133
CHEMBL361350
Rendered image for CHEMBL361350
CHEMBL182381
Rendered image for CHEMBL182381
CHEMBL364591
Rendered image for CHEMBL364591
CHEMBL183792
Rendered image for CHEMBL183792
CHEMBL182687
Rendered image for CHEMBL182687
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
6.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BIVM-ERCC5 readthrough [Source:HGNC Symbol;Acc:HGNC:43690]
Macaque
BIVM-ERCC5 readthrough [Source:HGNC Symbol;Acc:HGNC:43690]
Mouse
MGI:103582
22592
Rat
RGD:1586176
301382
Dog
ERCC excision repair 5, endonuclease
100855935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BIVM-ERCC5 readthrough [Source:HGNC Symbol;Acc:HGNC:43690]
Macaque
BIVM-ERCC5 readthrough [Source:HGNC Symbol;Acc:HGNC:43690]
Mouse
Rat
Dog
ERCC excision repair 5, endonuclease
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28715-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Gene Ontology Terms (23)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (177)
1 – 10 of 177
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  0.999999884
p_ni:  1.7e-8
p_wrong:  9.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCNH
Tbio
Novelty:  0.00693072
p_int:  0.999677744
p_ni:  2.25e-7
p_wrong:  0.000322031
Score:  0.99
Data Source:  BioPlex,STRINGDB
GTF2H2
Tbio
Novelty:  0.02761619
Score:  0.999
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.999
Data Source:  STRINGDB
GTF2H1
Tbio
Novelty:  0.01736328
Score:  0.999
Data Source:  STRINGDB
ERCC1
Tbio
Novelty:  0.00079472
Score:  0.996
Data Source:  Reactome,STRINGDB
ERCC4
Tbio
Family:  Enzyme
Novelty:  0.01076913
Score:  0.994
Data Source:  Reactome,STRINGDB
XPA
Tchem
Novelty:  0.00137698
Score:  0.991
Data Source:  STRINGDB
ERCC6
Tbio
Novelty:  0.00764502
Score:  0.98
Data Source:  STRINGDB
ERCC8
Tbio
Novelty:  0.02679635
Score:  0.979
Data Source:  STRINGDB
Publication Statistics
PubMed Score  120.06

PubMed score by year
PubTator Score  297

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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