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Tclin
RXRB
Retinoic acid receptor RXR-beta

Protein Summary
Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374680
  • ENSP00000363812
  • ENSG00000204231
  • ENST00000374685
  • ENSP00000363817
  • ENST00000383216
  • ENSP00000372703
  • ENSG00000206289
  • ENST00000383217
  • ENSP00000372704
  • ENST00000415157
  • ENSP00000402506
  • ENSG00000228333
  • ENST00000415909
  • ENSP00000410468
  • ENSG00000235712
  • ENST00000431161
  • ENSP00000393286
  • ENST00000431820
  • ENSP00000411238
  • ENSG00000231321
  • ENST00000436753
  • ENSP00000415199
  • ENSG00000227322
  • ENST00000443603
  • ENSP00000402590
  • ENST00000455462
  • ENSP00000400104
  • ENST00000456244
  • ENSP00000393870

Symbol
  • NR2B2
  • NR2B2
  • DAUDI6
  • RCoR-1
  • H-2RIIBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.9
disease perturbation
0.87
protein domain
0.85
biological process
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.47   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.47   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 66
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (80)
Items per page:
1 – 5 of 80
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
1.3
92.3
3
4
0
1.3
92.3
3
4
0
1.3
92.3
3
4
0
1.3
92.3
3
4
0
1.3
92.3
Items per page:
1 – 5 of 80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
92.3
0
1.3
92.3
0
1.3
92.3
0
1.3
92.3
0
1.3
92.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98215
20182
Rat
RGD:3611
361801
Dog
retinoid X receptor beta
VGNC:45818
481735
Horse
retinoid X receptor beta
VGNC:22640
100061303
Cow
retinoid X receptor beta
VGNC:34231
504943
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
retinoid X receptor beta
Horse
retinoid X receptor beta
Cow
retinoid X receptor beta
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28702-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Nuclear Receptor transcription pathway
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Nuclear Receptor transcription pathway
Gene Ontology Terms (13)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (110)
1 – 10 of 110
RARG
Tclin
Family:  NR
Novelty:  0.00667159
p_int:  0.999998109
p_ni:  0.000001781
p_wrong:  1.1e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
p_int:  0.999997526
p_ni:  0.000002427
p_wrong:  4.6e-8
Score:  0.978
Data Source:  BioPlex,STRINGDB
FLYWCH2
Tdark
Novelty:  1.44186144
p_int:  0.999997123
p_ni:  0.000002805
p_wrong:  7.2e-8
Score:  0.527
Data Source:  BioPlex,STRINGDB
RARA
Tclin
Family:  NR
Novelty:  0.00080574
p_int:  0.952632226
p_ni:  0.000109527
p_wrong:  0.047258247
Score:  0.998
Data Source:  BioPlex,STRINGDB
NR1H2
Tchem
Family:  NR
Novelty:  0.01296966
Score:  0.987
Data Source:  STRINGDB
NR1H3
Tchem
Family:  NR
Novelty:  0.00394862
Score:  0.984
Data Source:  Reactome,STRINGDB
RARB
Tclin
Family:  NR
Novelty:  0.00257427
Score:  0.982
Data Source:  Reactome,STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.982
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.98
Data Source:  Reactome,STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.979
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  60.47

PubMed score by year
PubTator Score  84.51

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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