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Tbio
MZF1
Myeloid zinc finger 1

Protein Summary
Description
Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215057
  • ENSP00000215057
  • ENSG00000099326
  • ENST00000594234
  • ENSP00000469378
  • ENST00000599369
  • ENSP00000469493

Symbol
  • MZF
  • ZNF42
  • ZSCAN6
  • MZF-1
  • MZF1B
  • ZFP98
  • ZNF42
  • ZSCAN6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.8
disease perturbation
0.79
protein domain
0.73
biological process
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.45   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.45   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
TWNK
Tbio
Novelty:  0.00393371
p_int:  0.999992441
p_ni:  0.000007559
Data Source:  BioPlex
ZSCAN1
Tbio
Family:  TF
Novelty:  0.0217244
p_int:  0.999989833
p_ni:  6.1e-8
p_wrong:  0.000010107
Score:  0.563
Data Source:  BioPlex,STRINGDB
DHRS2
Tbio
Family:  Enzyme
Novelty:  0.002032
p_int:  0.999942371
p_ni:  0.000053929
p_wrong:  0.0000037
Data Source:  BioPlex
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999792385
p_ni:  0.000207523
p_wrong:  9.2e-8
Data Source:  BioPlex
ZNF24
Tbio
Family:  TF
Novelty:  0.02954446
p_int:  0.999621222
p_ni:  0.000378778
Score:  0.415
Data Source:  BioPlex,STRINGDB
SCAND1
Tbio
Novelty:  0.06863895
p_int:  0.999065209
p_ni:  0.000929066
p_wrong:  0.000005725
Score:  0.475
Data Source:  BioPlex,STRINGDB
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.998620531
p_ni:  0.001371641
p_wrong:  0.000007828
Data Source:  BioPlex
ZNF213
Tbio
Family:  TF
Novelty:  0.24190639
p_int:  0.99437377
p_ni:  0.001341921
p_wrong:  0.004284309
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  0.938674001
p_ni:  0.061325997
p_wrong:  2e-9
Score:  0.259
Data Source:  BioPlex,STRINGDB
ZKSCAN1
Tbio
Family:  TF
Novelty:  0.08190662
p_int:  0.92440877
p_ni:  0.011743559
p_wrong:  0.06384767
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
78.7
mathematical ability
3
2
3
64
mean reticulocyte volume
1
1
1
49.5
red blood cell distribution width
1
1
1
49.5
intelligence
1
1
0
6.2
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
78.7
mathematical ability
3
64
mean reticulocyte volume
1
49.5
red blood cell distribution width
1
49.5
intelligence
0
6.2
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myeloid zinc finger 1
VGNC:2308
456356
Macaque
myeloid zinc finger 1
712144
Mouse
MGI:107457
109889
Rat
RGD:1308391
361508
Dog
myeloid zinc finger 1
VGNC:43594
484220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myeloid zinc finger 1
Macaque
myeloid zinc finger 1
Mouse
Rat
Dog
myeloid zinc finger 1
Publication Statistics
PubMed Score 79.45
PubMed score by year
PubTator Score 60.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title