Tchem HTR1E 5-hydroxytryptamine receptor 1E

Protein Summary

Description

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Uniprot Accession IDs

• P28566
• E1P503
• Q9P1Y1
• 5-HT-1E

Gene Name

• HTR1E

Ensembl ID

• ENST00000305344
• ENSP00000307766
• ENSG00000168830

Symbol

• 5-HT1E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
ligand (chemical)	0.99
molecular function	0.67
drug	0.6
small molecule perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / 5-hydroxytryptamine Receptor 1e

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / 5-hydroxytryptamine Receptor / 5-ht1 Receptor / 5-hydroxytryptamine Receptor 1e

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.82   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.82   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16