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Tchem
HTR1E
5-hydroxytryptamine receptor 1E

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305344
  • ENSP00000307766
  • ENSG00000168830

Symbol
  • 5-HT1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
ligand (chemical)
0.99
molecular function
0.67
drug
0.6
small molecule perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
clozapine
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olanzapine
Rendered image for olanzapine
risperidone
Rendered image for risperidone
ziprasidone
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quetiapine
Rendered image for quetiapine
zotepine
Rendered image for zotepine
yohimbine
Rendered image for yohimbine
sertindole
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dihydroergotamine
Rendered image for dihydroergotamine
lysergide
Rendered image for lysergide
Protein-Protein Interactions (270)
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.990898549
p_ni:  0.009101451
Score:  0.519
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.950032325
p_ni:  0.049967675
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.833134964
p_ni:  0.166865036
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.806212846
p_ni:  0.193787154
Data Source:  BioPlex
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.945
Data Source:  STRINGDB
HRH3
Tclin
Family:  GPCR
Novelty:  0.00148904
Score:  0.937
Data Source:  STRINGDB
RXFP4
Tchem
Family:  GPCR
Novelty:  0.05054041
Score:  0.931
Data Source:  STRINGDB
GRM3
Tchem
Family:  GPCR
Novelty:  0.00340947
Score:  0.928
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.928
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.928
Data Source:  STRINGDB
Pathways (16)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.3
70.6
wellbeing measurement
2
1
2
46.5
neuroticism measurement
1
1
1
33.8
depressive symptom measurement
1
1
1
28.6
neutrophil percentage of granulocytes
1
1
1
14.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
70.6
wellbeing measurement
2
46.5
neuroticism measurement
1
33.8
depressive symptom measurement
1
28.6
neutrophil percentage of granulocytes
1
14.8
Find similar targets by:
IDG Resources
Genetic Construct
HTR1E-Tango
image for HTR1E-Tango
Details:
  • Vector:  addgene66407
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • HTR1E-Tango
Order Genetic Construct from:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 1E
VGNC:7895
472064
Macaque
5-hydroxytryptamine receptor 1E
697598
Horse
5-hydroxytryptamine receptor 1E
VGNC:18901
100065574
Cow
5-hydroxytryptamine receptor 1E
VGNC:29994
616356
Opossum
5-hydroxytryptamine receptor 1E
100025139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 1E
Macaque
5-hydroxytryptamine receptor 1E
Horse
5-hydroxytryptamine receptor 1E
Cow
5-hydroxytryptamine receptor 1E
Opossum
5-hydroxytryptamine receptor 1E
Publication Statistics
PubMed Score 63.82
PubMed score by year
PubTator Score 33.64
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title