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Tchem
HTR1E
5-hydroxytryptamine receptor 1E

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305344
  • ENSP00000307766
  • ENSG00000168830

Symbol
  • 5-HT1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
ligand (chemical)
0.99
molecular function
0.67
drug
0.6
small molecule perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Pathways (16)
Amine ligand-binding receptors (R-HSA-375280)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (270)
1 – 10 of 270
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.02087315
p_int: 0.990898549
p_ni: 0.009101451
Score: 0.519
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.35273907
p_int: 0.950032325
p_ni: 0.049967675
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00100906
p_int: 0.833134964
p_ni: 0.166865036
Data Source: BioPlex
ACTB
Tbio
Novelty: 0.00027728
p_int: 0.806212846
p_ni: 0.193787154
Data Source: BioPlex
HTR5A
Tchem
Family: GPCR
Novelty: 0.01826019
Score: 0.945
Data Source: STRINGDB
HRH3
Tclin
Family: GPCR
Novelty: 0.00180244
Score: 0.937
Data Source: STRINGDB
RXFP4
Tbio
Family: GPCR
Novelty: 0.058923
Score: 0.931
Data Source: STRINGDB
GRM3
Tchem
Family: GPCR
Novelty: 0.00438401
Score: 0.928
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.14784205
Score: 0.928
Data Source: STRINGDB
HTR1A
Tclin
Family: GPCR
Novelty: 0.00019966
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.65

PubMed score by year
PubTator Score  33.64

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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