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Tchem
MAPK1
Mitogen-activated protein kinase 1

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215832
  • ENSP00000215832
  • ENSG00000100030
  • ENST00000398822
  • ENSP00000381803
  • ENST00000544786
  • ENSP00000440842

Symbol
  • ERK2
  • PRKM1
  • PRKM2
  • ERK
  • p38
  • p40
  • p41
  • ERK2
  • ERT1
  • ERK-2
  • MAPK2
  • PRKM1
  • PRKM2
  • P42MAPK
  • p41mapk
  • p42-MAPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1656.94   (req: < 5)
Gene RIFs: 1450   (req: <= 3)
Antibodies: 1683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1656.94   (req: >= 5)
Gene RIFs: 1450   (req: > 3)
Antibodies: 1683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 86
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2081
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1