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Tchem
MAPK1
Mitogen-activated protein kinase 1

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215832
  • ENSP00000215832
  • ENSG00000100030
  • ENST00000398822
  • ENSP00000381803
  • ENST00000544786
  • ENSP00000440842

Symbol
  • ERK2
  • PRKM1
  • PRKM2
  • ERK
  • p38
  • p40
  • p41
  • ERK2
  • ERT1
  • ERK-2
  • MAPK2
  • PRKM1
  • PRKM2
  • P42MAPK
  • p41mapk
  • p42-MAPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1421.81   (req: < 5)
Gene RIFs: 1450   (req: <= 3)
Antibodies: 1683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1421.81   (req: >= 5)
Gene RIFs: 1450   (req: > 3)
Antibodies: 1683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 86
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1919
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
87.4
body mass index
1
1
1
72.1
comparative body size at age 10, self-reported
1
1
1
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
87.4
body mass index
1
72.1
comparative body size at age 10, self-reported
1
26.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 1
VGNC:12896
458680
Macaque
mitogen-activated protein kinase 1
698569
Mouse
MGI:1346858
26413
Rat
RGD:70500
116590
Dog
mitogen-activated protein kinase 1
VGNC:42991
477575
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 1
Macaque
mitogen-activated protein kinase 1
Mouse
Rat
Dog
mitogen-activated protein kinase 1
Protein Structure (90 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28482-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 90
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (484)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 139
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of the AP-1 family of transcription factors
Advanced glycosylation endproduct receptor signaling
Apoptosis
Apoptotic factor-mediated response
Gene Ontology Terms (109)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (1096)
1 – 10 of 1096
PTPRR
Tbio
Family: Enzyme
Novelty: 0.02065754
p_int: 0.944602628
p_ni: 0.055397372
Score: 0.993
Data Source: BioPlex,STRINGDB
SPANXN4
Tdark
Novelty: 1.91062423
p_int: 0.889621086
p_ni: 0.110378914
Data Source: BioPlex
ECM1
Tbio
Novelty: 0.00518679
p_int: 0.818783534
p_ni: 0.181216466
Data Source: BioPlex
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.999
Data Source: Reactome,STRINGDB
DUSP6
Tbio
Family: Enzyme
Novelty: 0.00426304
Score: 0.998
Data Source: Reactome,STRINGDB
PEA15
Tbio
Novelty: 0.01075497
Score: 0.998
Data Source: Reactome,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.996
Data Source: STRINGDB
DUSP16
Tbio
Family: Enzyme
Novelty: 0.02881973
Score: 0.994
Data Source: STRINGDB
DUSP1
Tchem
Family: Enzyme
Novelty: 0.00097955
Score: 0.994
Data Source: STRINGDB
DUSP7
Tbio
Family: Enzyme
Novelty: 0.05499898
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1421.81

PubMed score by year
PubTator Score  13058.61

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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