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Tbio
GABRR2
Gamma-aminobutyric acid receptor subunit rho-2

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402938
  • ENSP00000386029
  • ENSG00000111886
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.91
gene perturbation
0.77
drug
0.75
tissue sample
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.72   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.72   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor rho2 subunit
700858
Mouse
MGI:95626
14409
Rat
RGD:61902
29695
Dog
gamma-aminobutyric acid type A receptor rho2 subunit
481918
Horse
gamma-aminobutyric acid type A receptor rho2 subunit
VGNC:18205
100070995
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor rho2 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor rho2 subunit
Horse
gamma-aminobutyric acid type A receptor rho2 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P28476-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (80)
1 – 10 of 80
GABRR1
Tchem
Family: IC
Novelty: 0.01601481
Score: 0.879
Data Source: Reactome,STRINGDB
GABRR3
Tbio
Family: IC
Novelty: 0.01890426
Score: 0.804
Data Source: Reactome,STRINGDB
CGA
Tbio
Novelty: 0.00394017
Score: 0.756
Data Source: STRINGDB
GABRA2
Tclin
Family: IC
Novelty: 0.00663529
Score: 0.72
Data Source: STRINGDB
GABRE
Tclin
Family: IC
Novelty: 0.03814541
Score: 0.72
Data Source: STRINGDB
GABRG3
Tclin
Family: IC
Novelty: 0.0420649
Score: 0.718
Data Source: STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.714
Data Source: STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.714
Data Source: STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.714
Data Source: STRINGDB
GABRG1
Tclin
Family: IC
Novelty: 0.04214561
Score: 0.714
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.72

PubMed score by year
PubTator Score  9.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer