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Tbio
HOXD10
Homeobox protein Hox-D10

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249501
  • ENSP00000249501
  • ENSG00000128710

Symbol
  • HOX4D
  • HOX4E
  • HOX4
  • HOX4D
  • HOX4E
  • Hox-4.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.77
gene perturbation
0.66
transcription factor perturbation
0.61
PubMedID
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (48)
1 – 10 of 48
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.98843755
p_ni:  0.01156245
Score:  0.228
Data Source:  BioPlex,STRINGDB
HOXD11
Tbio
Family:  TF
Novelty:  0.0195888
Score:  0.83
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.694
Data Source:  STRINGDB
HOXD9
Tbio
Family:  TF
Novelty:  0.01789716
Score:  0.635
Data Source:  STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.632
Data Source:  STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.617
Data Source:  STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
Score:  0.569
Data Source:  STRINGDB
HOXD8
Tbio
Family:  TF
Novelty:  0.03726604
Score:  0.562
Data Source:  STRINGDB
HOXD13
Tbio
Family:  TF
Novelty:  0.00404722
Score:  0.559
Data Source:  STRINGDB
GMNN
Tbio
Novelty:  0.00436572
Score:  0.543
Data Source:  STRINGDB
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
3
4
92.9
glomerular filtration rate
5
3
5
7.7
92.6
balding measurement
1
2
2
92.4
urate measurement
3
3
4
85.7
hematocrit
3
1
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
4
92.9
glomerular filtration rate
5
7.7
92.6
balding measurement
2
92.4
urate measurement
4
85.7
hematocrit
3
82.3
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox D10
VGNC:1962
739607
Mouse
MGI:96202
15430
Rat
RGD:1306511
303991
Dog
homeobox D10
VGNC:41762
609973
Horse
homeobox D10
VGNC:18852
100066123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox D10
Mouse
Rat
Dog
homeobox D10
Horse
homeobox D10
Publication Statistics
PubMed Score 96.00
PubMed score by year
PubTator Score 43.93
PubTator score by year