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Tbio
HOXD9
Homeobox protein Hox-D9

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249499
  • ENSP00000249499
  • ENSG00000128709

Symbol
  • HOX4C
  • HOX4
  • HOX4C
  • Hox-4.3
  • Hox-5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
protein domain
0.85
biological process
0.84
kinase perturbation
0.84
tissue sample
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.43   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.43   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (50)
1 – 10 of 50
HOXD4
Tbio
Family:  TF
Novelty:  0.01675267
Score:  0.875
Data Source:  STRINGDB
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
Score:  0.816
Data Source:  STRINGDB
HOXA5
Tbio
Family:  TF
Novelty:  0.0058504
Score:  0.804
Data Source:  STRINGDB
HOXC5
Tbio
Family:  TF
Novelty:  0.05354226
Score:  0.803
Data Source:  STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
Score:  0.792
Data Source:  STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
Score:  0.79
Data Source:  STRINGDB
HOXB4
Tbio
Family:  TF
Novelty:  0.00598207
Score:  0.773
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.766
Data Source:  STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.751
Data Source:  STRINGDB
HAND2
Tbio
Family:  TF
Novelty:  0.00478924
Score:  0.743
Data Source:  STRINGDB
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
3
4
92.9
glomerular filtration rate
5
3
5
7.7
92.6
balding measurement
1
2
2
92.4
urate measurement
3
3
4
85.7
hematocrit
3
1
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
4
92.9
glomerular filtration rate
5
7.7
92.6
balding measurement
2
92.4
urate measurement
4
85.7
hematocrit
3
82.3
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96210
15438
Rat
RGD:1582908
688999
Horse
homeobox D9
VGNC:18854
100053496
Cow
homeobox D9
VGNC:29934
100295338
Pig
homeobox D9
110255183
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
homeobox D9
Cow
homeobox D9
Pig
homeobox D9
Publication Statistics
PubMed Score 58.43
PubMed score by year
PubTator Score 30.73
PubTator score by year