Tchem TEAD1 Transcriptional enhancer factor TEF-1

Protein Summary

Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P28347
• A4FUP2
• E7EV65

Gene Name

• TEAD1

Ensembl ID

• ENST00000334310
• ENSP00000334754
• ENSG00000187079
• ENST00000638666
• ENSP00000491500

Symbol

• TCF13
• TEF1
• AA
• REF1
• TCF13
• TEF-1
• NTEF-1
• TCF-13
• TEAD-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.85
transcription factor binding site profile	0.81
PubMedID	0.74
transcription factor perturbation	0.74
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-1

DTO Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.2   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.2   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0