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Tclin
HTR2C
5-hydroxytryptamine receptor 2C

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276198
  • ENSP00000276198
  • ENSG00000147246
  • ENST00000371950
  • ENSP00000361018
  • ENST00000371951
  • ENSP00000361019

Symbol
  • HTR1C
  • HTR1C
  • 5-HT1C
  • 5-HT2C
  • 5HTR2C
  • 5-HTR2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
biological process
0.97
disease
0.8
phenotype
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1264.28   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1264.28   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1143
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 50
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (354)
1 – 10 of 354
TAPBP
Tbio
Novelty: 0.00308518
p_int: 0.999957335
p_ni: 0.000040389
p_wrong: 0.000002276
Score: 0.189
Data Source: BioPlex,STRINGDB
RETREG2
Tdark
Novelty: 0.375
p_int: 0.999956811
p_ni: 0.00004318
p_wrong: 9e-9
Data Source: BioPlex
KLRG2
Tdark
Novelty: 0.77419355
p_int: 0.999853041
p_ni: 0.000146951
p_wrong: 8e-9
Data Source: BioPlex
CERS5
Tbio
Family: TF
Novelty: 0.04558376
p_int: 0.999743107
p_ni: 0.000256892
Data Source: BioPlex
SLC35F1
Tdark
Family: Transporter
Novelty: 0.71189535
p_int: 0.999715468
p_ni: 0.000129621
p_wrong: 0.00015491
Score: 0.197
Data Source: BioPlex,STRINGDB
FAM210B
Tbio
Novelty: 0.25174825
p_int: 0.999611314
p_ni: 0.000385374
p_wrong: 0.000003312
Data Source: BioPlex
UBE2Q1
Tbio
Novelty: 0.07843137
p_int: 0.999458883
p_ni: 0.000541117
Data Source: BioPlex
C6orf47
Tdark
Novelty: 0.27025154
p_int: 0.999178808
p_ni: 0.000265598
p_wrong: 0.000555594
Score: 0.199
Data Source: BioPlex,STRINGDB
HMOX2
Tchem
Family: Enzyme
Novelty: 0.00171143
p_int: 0.998820445
p_ni: 0.001179555
Data Source: BioPlex
ITPRIPL1
Tdark
p_int: 0.998429732
p_ni: 0.001570268
Data Source: BioPlex
Publication Statistics
PubMed Score  1264.28

PubMed score by year
PubTator Score  469.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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