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Tclin
HTR2C
5-hydroxytryptamine receptor 2C

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276198
  • ENSP00000276198
  • ENSG00000147246
  • ENST00000371950
  • ENSP00000361018
  • ENST00000371951
  • ENSP00000361019

Symbol
  • HTR1C
  • HTR1C
  • 5-HT1C
  • 5-HT2C
  • 5HTR2C
  • 5-HTR2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
biological process
0.97
disease
0.8
phenotype
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1272.37   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1272.37   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1470
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 52
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (52)
clozapine
Rendered image for clozapine
chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
clemastine
Rendered image for clemastine
cyproheptadine
Rendered image for cyproheptadine
fluphenazine
Rendered image for fluphenazine
Protein-Protein Interactions (354)
TAPBP
Tbio
Novelty:  0.00328098
p_int:  0.999957335
p_ni:  0.000040389
p_wrong:  0.000002276
Score:  0.189
Data Source:  BioPlex,STRINGDB
RETREG2
Tdark
Novelty:  0.18851807
p_int:  0.999956811
p_ni:  0.00004318
p_wrong:  9e-9
Data Source:  BioPlex
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999853041
p_ni:  0.000146951
p_wrong:  8e-9
Data Source:  BioPlex
CERS5
Tbio
Family:  TF
Novelty:  0.02984012
p_int:  0.999743107
p_ni:  0.000256892
Data Source:  BioPlex
SLC35F1
Tdark
Family:  Transporter
Novelty:  0.34046601
p_int:  0.999715468
p_ni:  0.000129621
p_wrong:  0.00015491
Score:  0.197
Data Source:  BioPlex,STRINGDB
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.999611314
p_ni:  0.000385374
p_wrong:  0.000003312
Data Source:  BioPlex
UBE2Q1
Tbio
Novelty:  0.06489765
p_int:  0.999458883
p_ni:  0.000541117
Data Source:  BioPlex
C6orf47
Tdark
Novelty:  0.12805293
p_int:  0.999178808
p_ni:  0.000265598
p_wrong:  0.000555594
Score:  0.199
Data Source:  BioPlex,STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
p_int:  0.998820445
p_ni:  0.001179555
Data Source:  BioPlex
ITPRIPL1
Tdark
Novelty:  3.09953366
p_int:  0.998429732
p_ni:  0.001570268
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 2C
VGNC:7460
473740
Macaque
5-hydroxytryptamine receptor 2C
708141
Mouse
MGI:96281
15560
Rat
RGD:2848
25187
Dog
5-hydroxytryptamine receptor 2C
VGNC:41828
450240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 2C
Macaque
5-hydroxytryptamine receptor 2C
Mouse
Rat
Dog
5-hydroxytryptamine receptor 2C
Publication Statistics
PubMed Score 1272.37
PubMed score by year
PubTator Score 469.82
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title