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Tclin
NDUFS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233190
  • ENSP00000233190
  • ENSG00000023228
  • ENST00000423725
  • ENSP00000397760
  • ENST00000432169
  • ENSP00000409689
  • ENST00000440274
  • ENSP00000409766
  • ENST00000449699
  • ENSP00000399912
  • ENST00000455934
  • ENSP00000392709
  • ENST00000635748
  • ENSP00000489640
  • ENSG00000283447
  • ENST00000636505
  • ENSP00000490898
  • ENST00000637298
  • ENSP00000490583
  • ENST00000637631
  • ENSP00000489705
  • ENST00000637733
  • ENSP00000490092
  • ENST00000637990
  • ENSP00000490766

Symbol
  • CI-75k
  • MC1DN5
  • CI-75Kd
  • PRO1304
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
protein domain
0.97
kinase perturbation
0.96
virus perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.42   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.42   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
73.2
self reported educational attainment
1
1
1
73.2
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
73.2
self reported educational attainment
1
73.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S1
VGNC:6112
459896
Macaque
NADH:ubiquinone oxidoreductase core subunit S1
706912
Mouse
MGI:2443241
227197
Rat
RGD:1359670
301458
Dog
NADH:ubiquinone oxidoreductase core subunit S1
478880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S1
Macaque
NADH:ubiquinone oxidoreductase core subunit S1
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit S1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28331-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999946801
p_ni: 0.000053199
Score: 0.998
Data Source: BioPlex,STRINGDB
PML
Tbio
Novelty: 0.00285474
p_int: 0.989181776
p_ni: 0.010818224
Score: 0.176
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.982342493
p_ni: 0.017657507
Score: 0.989
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.979598413
p_ni: 0.020401587
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.977760893
p_ni: 0.022239107
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.946380245
p_ni: 0.053619755
Score: 0.998
Data Source: BioPlex,STRINGDB
METTL2A
Tdark
Family: Enzyme
Novelty: 0.72443397
p_int: 0.942131708
p_ni: 0.057868292
Score: 0.58
Data Source: BioPlex,STRINGDB
HSFY1
Tdark
Family: TF
p_int: 0.920145226
p_ni: 0.079854774
Data Source: BioPlex
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.919578817
p_ni: 0.080421183
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.905396757
p_ni: 0.094603243
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  44.42

PubMed score by year
PubTator Score  25.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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