Tclin NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P28331
• B4DIN9
• B4DJA0
• B4DPG1
• B4DUC1
• E7ENF3
• Q53TR8
• Q8N1C4
• Q8TCC9

Gene Name

• NDUFS1

Ensembl ID

• ENST00000233190
• ENSP00000233190
• ENSG00000023228
• ENST00000423725
• ENSP00000397760
• ENST00000432169
• ENSP00000409689
• ENST00000440274
• ENSP00000409766
• ENST00000449699
• ENSP00000399912
• ENST00000455934
• ENSP00000392709
• ENST00000635748
• ENSP00000489640
• ENSG00000283447
• ENST00000636505
• ENSP00000490898
• ENST00000637298
• ENSP00000490583
• ENST00000637631
• ENSP00000489705
• ENST00000637733
• ENSP00000490092
• ENST00000637990
• ENSP00000490766

Symbol

• CI-75k
• MC1DN5
• CI-75Kd
• PRO1304

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
protein domain	0.97
kinase perturbation	0.96
virus perturbation	0.95

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh-ubiquinone Oxidoreductase 75 Kda Subunit, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh-ubiquinone Oxidoreductase 75 Kda Subunit, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh-ubiquinone Oxidoreductase 75 Kda Subunit, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.7   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.7   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1