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Tchem
CHAT
Choline O-acetyltransferase

Protein Summary
Description
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337653
  • ENSP00000337103
  • ENSG00000070748
  • ENST00000339797
  • ENSP00000343486
  • ENST00000351556
  • ENSP00000345878
  • ENST00000395559
  • ENSP00000378926
  • ENST00000395562
  • ENSP00000378929

Symbol
  • CMS6
  • CMS1A
  • CMS1A2
  • CHOACTASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.9
chemical
0.85
disease
0.7
biological process
0.69
cellular component
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3235.1   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 588   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3235.1   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 588   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
66.3
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
66.3
1
47.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
choline O-acetyltransferase
VGNC:14505
450451
Macaque
choline O-acetyltransferase
709977
Mouse
MGI:88392
12647
Rat
RGD:1304627
290567
Dog
choline O-acetyltransferase
VGNC:39192
486775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
choline O-acetyltransferase
Macaque
choline O-acetyltransferase
Mouse
Rat
Dog
choline O-acetyltransferase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28329-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Neuronal System
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (166)
1 – 10 of 166
SLC18A3
Tchem
Family:  Transporter
Novelty:  0.00169007
Score:  0.956
Data Source:  STRINGDB
ACHE
Tclin
Family:  Enzyme
Novelty:  0.00026957
Score:  0.941
Data Source:  STRINGDB
CHKA
Tchem
Family:  Kinase
Novelty:  0.00237839
Score:  0.931
Data Source:  STRINGDB
GPCPD1
Tdark
Family:  Enzyme
Novelty:  0.03548168
Score:  0.904
Data Source:  STRINGDB
CHKB
Tbio
Family:  Kinase
Novelty:  0.00862294
Score:  0.903
Data Source:  STRINGDB
PHOSPHO1
Tchem
Family:  Enzyme
Novelty:  0.05458897
Score:  0.9
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.887
Data Source:  STRINGDB
SLC25A20
Tbio
Family:  Transporter
Novelty:  0.00503518
Score:  0.874
Data Source:  STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.872
Data Source:  STRINGDB
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
Score:  0.843
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3235.10

PubMed score by year
PubTator Score  118.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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