Tchem CHAT Choline O-acetyltransferase

Protein Summary

Description

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P28329
• A2BDF4
• A2BDF5
• Q16488
• Q9BQ23
• Q9BQ35
• Q9BQE1
• CHOACTase

Gene Name

• CHAT

Ensembl ID

• ENST00000337653
• ENSP00000337103
• ENSG00000070748
• ENST00000339797
• ENSP00000343486
• ENST00000351556
• ENSP00000345878
• ENST00000395559
• ENSP00000378926
• ENST00000395562
• ENSP00000378929

Symbol

• CMS6
• CMS1A
• CMS1A2
• CHOACTASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.9
chemical	0.85
disease	0.7
biological process	0.69
cellular component	0.69

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Choline O-acetyltransferase

Protein / Transferase / Acetyltransferase / Choline O-acetyltransferase

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Choline O-acetyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3408.94   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 588   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3408.94   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 588   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0