Tbio CST5 Cystatin-D

Protein Summary

Description

Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28325
• Q5JRF5
• Q9UCA0

Gene Name

• CST5

Ensembl ID

• ENST00000304710
• ENSP00000307132
• ENSG00000170367

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.84
cell line	0.51
tissue sample	0.47
cell type or tissue	0.44
chemical	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.16   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.16   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

FKBP15

Tbio

Novelty:  0.0570695

p_int:  0.999999986

p_ni:  1.4e-8

Data Source:  BioPlex

MCAM

Tbio

Novelty:  0.00128524

p_int:  0.999996857

p_ni:  0.000003114

p_wrong:  2.9e-8

Data Source:  BioPlex

SIRT2

Tchem

Family:  Epigenetic

Novelty:  0.00093962

p_int:  0.999988597

p_ni:  0.000011403

Data Source:  BioPlex

CTSH

Tchem

Family:  Enzyme

Novelty:  0.00336694

p_int:  0.999956686

p_ni:  0.000043314

Score:  0.473

Data Source:  BioPlex,STRINGDB

ENDOG

Tbio

Family:  Enzyme

Novelty:  0.00404275

p_int:  0.999954876

p_ni:  0.000040628

p_wrong:  0.000004495

Data Source:  BioPlex

TENM3

Tbio

Novelty:  0.0251948

p_int:  0.999893159

p_ni:  0.000106841

Data Source:  BioPlex

BCHE

Tclin

Family:  Enzyme

Novelty:  0.00031267

p_int:  0.997833732

p_ni:  0.002165422

p_wrong:  8.46e-7

Data Source:  BioPlex

RCAN1

Tbio

Novelty:  0.0030009

p_int:  0.994114291

p_ni:  0.000103941

p_wrong:  0.005781768

Score:  0.19

Data Source:  BioPlex,STRINGDB

KIR2DS2

Tdark

p_int:  0.994052807

p_ni:  0.000075622

p_wrong:  0.005871572

Data Source:  BioPlex

SNRPF

Tdark

Novelty:  0.17624854

p_int:  0.990892694

p_ni:  0.000069337

p_wrong:  0.009037969

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (59)

KEGG (1)

WikiPathways (58)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Salivary secretion	90 targets	path:hsa04970

Name	Explore in Pharos	Explore in Source
Salivary secretion	90 targets	path:hsa04970

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (3)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
cysteine-type endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cystatin-D measurement	EFO_0008103	1	1	1		39.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cystatin-D measurement	EFO_0008103	1		39.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Signal
Thiol protease inhibitor

GWAS Trait Find Similar Targets

No Header	No Header
cystatin-D measurement

MGI Phenotype Find Similar Targets

No Header	No Header
limbs/digits/tail phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	cystatin D		704408
Zebrafish	zgc:163030	ZDB-GENE-060810-77	566959

Species	Name	OMA	EggNOG	Inparanoid
Macaque	cystatin D
Zebrafish	zgc:163030

Publication Statistics

PubMed Score 25.16

PubMed score by year

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PubTator Score 19.38

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (7)

Items per page:

10

0 of 0

PMID	Year	Title