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Tbio
CST5
Cystatin-D

Protein Summary
Description
Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304710
  • ENSP00000307132
  • ENSG00000170367
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
cell line
0.51
tissue sample
0.47
cell type or tissue
0.44
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.16   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.16   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
FKBP15
Tbio
Novelty:  0.0570695
p_int:  0.999999986
p_ni:  1.4e-8
Data Source:  BioPlex
MCAM
Tbio
Novelty:  0.00128524
p_int:  0.999996857
p_ni:  0.000003114
p_wrong:  2.9e-8
Data Source:  BioPlex
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.999988597
p_ni:  0.000011403
Data Source:  BioPlex
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.999956686
p_ni:  0.000043314
Score:  0.473
Data Source:  BioPlex,STRINGDB
ENDOG
Tbio
Family:  Enzyme
Novelty:  0.00404275
p_int:  0.999954876
p_ni:  0.000040628
p_wrong:  0.000004495
Data Source:  BioPlex
TENM3
Tbio
Novelty:  0.0251948
p_int:  0.999893159
p_ni:  0.000106841
Data Source:  BioPlex
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.997833732
p_ni:  0.002165422
p_wrong:  8.46e-7
Data Source:  BioPlex
RCAN1
Tbio
Novelty:  0.0030009
p_int:  0.994114291
p_ni:  0.000103941
p_wrong:  0.005781768
Score:  0.19
Data Source:  BioPlex,STRINGDB
KIR2DS2
Tdark
p_int:  0.994052807
p_ni:  0.000075622
p_wrong:  0.005871572
Data Source:  BioPlex
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.990892694
p_ni:  0.000069337
p_wrong:  0.009037969
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystatin-D measurement
1
1
1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystatin-D measurement
1
39.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cystatin D
704408
Zebrafish
ZDB-GENE-060810-77
566959
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cystatin D
Zebrafish
Publication Statistics
PubMed Score 25.16
PubMed score by year
PubTator Score 19.38
PubTator score by year
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Related Publications
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PMID
Year
Title