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Tbio
ELK4
ETS domain-containing protein Elk-4

Protein Summary
Description
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289703
  • ENSP00000289703
  • ENSG00000158711
  • ENST00000357992
  • ENSP00000350681
  • ENST00000616704
  • ENSP00000483628

Symbol
  • SAP1
  • SAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.95
kinase perturbation
0.93
microRNA
0.78
transcription factor
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.966
Data Source:  STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.938
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.914
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.905
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.894
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.836
Data Source:  STRINGDB
MAPK13
Tchem
Family:  Kinase
Novelty:  0.01071621
Score:  0.825
Data Source:  STRINGDB
ELK1
Tbio
Family:  TF
Novelty:  0.21670414
Score:  0.812
Data Source:  STRINGDB
SLC45A3
Tbio
Family:  Transporter
Novelty:  0.0178929
Score:  0.732
Data Source:  STRINGDB
EGR1
Tbio
Family:  TF
Novelty:  0.00039994
Score:  0.712
Data Source:  STRINGDB
Pathways (213)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Human T-cell leukemia virus 1 infection
KEGG
MAPK signaling pathway
KEGG
Transcriptional misregulation in cancer
Name
Explore in Pharos
Explore in Source
Human T-cell leukemia virus 1 infection
MAPK signaling pathway
Transcriptional misregulation in cancer
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
5
5
5
97.2
basophil count
5
5
5
91.7
Parkinson disease
1
1
1
61.1
leukocyte count
2
2
2
45.7
bowel opening frequency
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
5
97.2
basophil count
5
91.7
Parkinson disease
1
61.1
leukocyte count
2
45.7
bowel opening frequency
1
41.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELK4, ETS transcription factor
VGNC:8319
742304
Macaque
ELK4, ETS transcription factor
699281
Mouse
MGI:102853
13714
Rat
RGD:1310504
304786
Dog
ELK4, ETS transcription factor
VGNC:40305
488574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELK4, ETS transcription factor
Macaque
ELK4, ETS transcription factor
Mouse
Rat
Dog
ELK4, ETS transcription factor
Publication Statistics
PubMed Score 29.88
PubMed score by year
PubTator Score 19.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title