Tbio ELK4 ETS domain-containing protein Elk-4

Protein Summary

Description

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28324
• P28323
• Q6GSJ2

Gene Name

• ELK4

Ensembl ID

• ENST00000289703
• ENSP00000289703
• ENSG00000158711
• ENST00000357992
• ENSP00000350681
• ENST00000616704
• ENSP00000483628

Symbol

• SAP1
• SAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.95
kinase perturbation	0.93
microRNA	0.78
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ets Domain-containing Protein Elk-4

Protein / Signaling Molecule / Ets Domain-containing Protein Elk-4

Protein / Nucleic Acid Binding / Ets Domain-containing Protein Elk-4

Protein / ... / Winged Helix/forkhead Transcription Factor / Ets Domain-containing Protein Elk-4

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Ets Domain-containing Protein Elk-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.88   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.88   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0