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Tbio
LOX
Protein-lysine 6-oxidase

Protein Summary
Description
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231004
  • ENSP00000231004
  • ENSG00000113083
  • ENST00000639739
  • ENSP00000492324

Symbol
  • AAT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
PubMedID
0.93
biological term
0.84
disease
0.82
small molecule perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3567.96   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3567.96   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
64.6
intraocular pressure measurement
1
2
2
52
1
1
0
1.1
44.8
central corneal thickness
1
1
0
1.7
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
64.6
intraocular pressure measurement
2
52
0
1.1
44.8
central corneal thickness
0
1.7
7.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase
VGNC:4072
471614
Mouse
MGI:96817
16948
Rat
RGD:3015
24914
Dog
lysyl oxidase
VGNC:42737
481478
Cow
lysyl oxidase
VGNC:30951
280841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase
Mouse
Rat
Dog
lysyl oxidase
Cow
lysyl oxidase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P28300-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Elastic fibre formation
Extracellular matrix organization
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (228)
1 – 10 of 228
PDE7A
Tclin
Family: Enzyme
Novelty: 0.00872596
p_int: 0.999985195
p_ni: 0.000014708
p_wrong: 9.7e-8
Data Source: BioPlex
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999965734
p_ni: 0.000034266
Data Source: BioPlex
TTC19
Tbio
Novelty: 0.08251578
p_int: 0.999060807
p_ni: 0.000939193
Data Source: BioPlex
N4BP2L2
Tbio
Novelty: 0.24527466
p_int: 0.976493928
p_ni: 0.023502931
p_wrong: 0.000003141
Data Source: BioPlex
ARNT
Tbio
Family: TF
Novelty: 0.00183071
p_int: 0.956853332
p_ni: 0.043145795
p_wrong: 8.73e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
VWA8
Tdark
Novelty: 0.17546432
p_int: 0.931853641
p_ni: 0.068146359
Data Source: BioPlex
GTPBP1
Tbio
Novelty: 0.00160825
p_int: 0.919018105
p_ni: 0.080981895
Data Source: BioPlex
ALG13
Tbio
Family: Enzyme
Novelty: 0.04054611
p_int: 0.856112896
p_ni: 0.143887104
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.825766301
p_ni: 0.174233699
Score: 0.174
Data Source: BioPlex,STRINGDB
ZMYM2
Tbio
Novelty: 0.0258698
p_int: 0.77108505
p_ni: 0.22891495
Data Source: BioPlex
Publication Statistics
PubMed Score  3567.96

PubMed score by year
PubTator Score  622.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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