Tbio ABCD3 ATP-binding cassette sub-family D member 3

Protein Summary

Description

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28288
• D3DT46
• Q15271
• Q6NUN5
• Q96DA3
• Q9H529

Gene Name

• ABCD3

Ensembl ID

• ENST00000315713
• ENSP00000326880
• ENSG00000117528
• ENST00000370214
• ENSP00000359233

Symbol

• PMP70
• PXMP1
• ZWS2
• ABC43
• CBAS5
• PMP70
• PXMP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
disease perturbation	0.95
kinase perturbation	0.91
transcription factor perturbation	0.88
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette Sub-family D Member 3

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcd Subfamily Of Peroxisomal Abc Transporters / Atp-binding Cassette Sub-family D Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.47   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.47   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0