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Tbio
ABCD3
ATP-binding cassette sub-family D member 3

Protein Summary
Description
Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315713
  • ENSP00000326880
  • ENSG00000117528
  • ENST00000370214
  • ENSP00000359233

Symbol
  • PMP70
  • PXMP1
  • ZWS2
  • ABC43
  • CBAS5
  • PMP70
  • PXMP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.95
kinase perturbation
0.91
transcription factor perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.9   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.9   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
1 – 10 of 83
PEX3
Tbio
Novelty:  0.01171119
Score:  0.995
Data Source:  Reactome,STRINGDB
PEX19
Tbio
Novelty:  0.00605342
Score:  0.991
Data Source:  Reactome,STRINGDB
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
Score:  0.984
Data Source:  Reactome,STRINGDB
ABCD2
Tbio
Family:  Transporter
Novelty:  0.01352365
Score:  0.946
Data Source:  Reactome,STRINGDB
SLC25A17
Tbio
Family:  Transporter
Novelty:  0.00601179
Score:  0.92
Data Source:  STRINGDB
AGPS
Tbio
Family:  Enzyme
Novelty:  0.01075549
Score:  0.885
Data Source:  STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.879
Data Source:  STRINGDB
PEX16
Tbio
Novelty:  0.03119723
Score:  0.876
Data Source:  STRINGDB
PEX11B
Tbio
Novelty:  0.04285427
Score:  0.87
Data Source:  STRINGDB
PEX5
Tbio
Novelty:  0.00560901
Score:  0.864
Data Source:  STRINGDB
Pathways (14)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Class I peroxisomal membrane protein import
Protein localization
Transport of small molecules
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue factor measurement
1
2
2
74.1
platelet count
1
1
1
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue factor measurement
2
74.1
platelet count
1
17.7
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily D member 3
VGNC:23
100615571
Macaque
ATP binding cassette subfamily D member 3
709188
Mouse
MGI:1349216
19299
Rat
RGD:2007
25270
Dog
ATP binding cassette subfamily D member 3
VGNC:37447
479939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily D member 3
Macaque
ATP binding cassette subfamily D member 3
Mouse
Rat
Dog
ATP binding cassette subfamily D member 3
Publication Statistics
PubMed Score 88.90
PubMed score by year
PubTator Score 71.71
PubTator score by year