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Tclin
HTR1D
5-hydroxytryptamine receptor 1D

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374619
  • ENSP00000363748
  • ENSG00000179546

Symbol
  • HTR1DA
  • HTRL
  • HTRL
  • RDC4
  • HT1DA
  • 5-HT1D
  • HTR1DA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.96
disease perturbation
0.79
gene perturbation
0.72
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.65   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.65   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 853
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 27
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (27)
clozapine
Rendered image for clozapine
olanzapine
Rendered image for olanzapine
aripiprazole
Rendered image for aripiprazole
lisuride
Rendered image for lisuride
haloperidol
Rendered image for haloperidol
ziprasidone
Rendered image for ziprasidone
quetiapine
Rendered image for quetiapine
bromocriptine
Rendered image for bromocriptine
ergotamine
Rendered image for ergotamine
pergolide
Rendered image for pergolide
Protein-Protein Interactions (253)
GNG7
Tbio
Novelty:  0.08478455
Score:  0.939
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.937
Data Source:  STRINGDB
HTR1B
Tclin
Family:  GPCR
Novelty:  0.00073663
Score:  0.933
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.933
Data Source:  STRINGDB
GRM2
Tchem
Family:  GPCR
Novelty:  0.00132156
Score:  0.93
Data Source:  STRINGDB
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
Score:  0.929
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.928
Data Source:  STRINGDB
GRM4
Tchem
Family:  GPCR
Novelty:  0.00380434
Score:  0.927
Data Source:  STRINGDB
GRM7
Tchem
Family:  GPCR
Novelty:  0.00416377
Score:  0.923
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
77.9
BMI-adjusted hip circumference
1
3
3
74.9
monocyte percentage of leukocytes
1
1
1
57.3
body mass index
1
1
1
40.7
waist-hip ratio
2
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
77.9
BMI-adjusted hip circumference
3
74.9
monocyte percentage of leukocytes
1
57.3
body mass index
1
40.7
waist-hip ratio
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
5-hydroxytryptamine receptor 1D
709379
Mouse
MGI:96276
15552
Rat
RGD:2847
25323
Dog
5-hydroxytryptamine receptor 1D
VGNC:41824
403963
Horse
5-hydroxytryptamine receptor 1D
VGNC:18900
100071630
Species
Name
OMA
EggNOG
Inparanoid
Macaque
5-hydroxytryptamine receptor 1D
Mouse
Rat
Dog
5-hydroxytryptamine receptor 1D
Horse
5-hydroxytryptamine receptor 1D
Publication Statistics
PubMed Score 393.65
PubMed score by year
PubTator Score 221.60
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title