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Tchem
GSTM2
Glutathione S-transferase Mu 2

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 20 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241337
  • ENSP00000241337
  • ENSG00000213366
  • ENST00000442650
  • ENSP00000416883
  • ENST00000460717
  • ENSP00000435910

Symbol
  • GST4
  • GST4
  • GSTM
  • GTHMUS
  • GSTM2-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.86
disease
0.81
chemical
0.8
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.38   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.38   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (34)
CHEMBL3360523
Rendered image for CHEMBL3360523
CHEMBL3360520
Rendered image for CHEMBL3360520
CHEMBL3360522
Rendered image for CHEMBL3360522
CHEMBL3360504
Rendered image for CHEMBL3360504
CHEMBL3360532
Rendered image for CHEMBL3360532
CHEMBL3360531,CHEMBL2430532
Rendered image for CHEMBL3360531,CHEMBL2430532
CHEMBL3360530
Rendered image for CHEMBL3360530
CHEMBL3360518
Rendered image for CHEMBL3360518
CHEMBL3360535
Rendered image for CHEMBL3360535
CHEMBL3360513
Rendered image for CHEMBL3360513
Protein-Protein Interactions (106)
GSTM5
Tbio
Family:  Enzyme
Novelty:  0.03763535
p_int:  1
Score:  0.959
Data Source:  BioPlex,STRINGDB
GSTM4
Tbio
Family:  Enzyme
Novelty:  0.03845761
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
p_int:  0.999999877
p_ni:  1.23e-7
Score:  0.99
Data Source:  BioPlex,STRINGDB
GSTM1
Tbio
Family:  Enzyme
Novelty:  0.00023264
Score:  0.96
Data Source:  STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.902
Data Source:  STRINGDB
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
Score:  0.885
Data Source:  STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
Score:  0.882
Data Source:  STRINGDB
GSTA4
Tbio
Family:  Enzyme
Novelty:  0.01099229
Score:  0.878
Data Source:  STRINGDB
GPX1
Tbio
Family:  Enzyme
Novelty:  0.000826
Score:  0.871
Data Source:  STRINGDB
GPX5
Tbio
Family:  Enzyme
Novelty:  0.01204448
Score:  0.87
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (19)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
8
8
98.1
low density lipoprotein cholesterol measurement
2
4
4
95
apolipoprotein A 1 measurement
1
2
2
93.6
high density lipoprotein cholesterol measurement
1
2
2
92.7
body mass index
9
2
16
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
8
98.1
low density lipoprotein cholesterol measurement
4
95
apolipoprotein A 1 measurement
2
93.6
high density lipoprotein cholesterol measurement
2
92.7
body mass index
16
91.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915562
68312
Mouse
MGI:95861
14863
Horse
glutathione S-transferase Mu 1-like
100058329
Xenopus
glutathione S-transferase mu 1
XB-GENE-971384
448387
Zebrafish
ZDB-GENE-050309-24
568744
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Mouse
Horse
glutathione S-transferase Mu 1-like
Xenopus
glutathione S-transferase mu 1
Zebrafish
Publication Statistics
PubMed Score 286.38
PubMed score by year
PubTator Score 153.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title