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Tclin
PSMB5
Proteasome subunit beta type-5

Protein Summary
Description
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. The proteasome is a mu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361611
  • ENSP00000355325
  • ENSG00000100804
  • ENST00000425762
  • ENSP00000395206
  • ENST00000493471
  • ENSP00000452424

Symbol
  • LMPX
  • MB1
  • X
  • X
  • MB1
  • LMPX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
kinase perturbation
0.95
disease perturbation
0.93
hub protein
0.82
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.7   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.7   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 531
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (531)
epigallocatechin gallate
Rendered image for epigallocatechin gallate
Apigenin
Rendered image for Apigenin
CHEMBL4297468
Rendered image for CHEMBL4297468
Delanzomib
Rendered image for Delanzomib
Epicatechin gallate
Rendered image for Epicatechin gallate
CHEMBL4465456
Rendered image for CHEMBL4465456
CHEMBL4128898
Rendered image for CHEMBL4128898
CHEMBL4452892
Rendered image for CHEMBL4452892
Halicyclamine B
Rendered image for Halicyclamine B
CHEMBL4167623
Rendered image for CHEMBL4167623
Protein-Protein Interactions (258)
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
p_int:  0.999087056
p_ni:  0.000912944
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.998974807
p_ni:  0.001025193
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
p_int:  0.998954805
p_ni:  0.001045195
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.998197211
p_ni:  0.001802789
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
p_int:  0.994307898
p_ni:  0.005692102
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.989218127
p_ni:  0.010781873
Score:  0.997
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.980500682
p_ni:  0.019499318
Score:  0.999
Data Source:  BioPlex,STRINGDB
SLC25A31
Tbio
Family:  Transporter
Novelty:  0.02122923
p_int:  0.977078047
p_ni:  6.7e-8
p_wrong:  0.022921885
Data Source:  BioPlex
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.949712466
p_ni:  0.050287534
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.855678623
p_ni:  0.144321377
Score:  0.981
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (155)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
6
10
99.4
eosinophil count
3
5
7
98
basophil count
5
7
9
98
eosinophil percentage of leukocytes
2
7
9
97
reticulocyte count
6
3
6
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.4
eosinophil count
7
98
basophil count
9
98
eosinophil percentage of leukocytes
9
97
reticulocyte count
6
97
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit beta 5
VGNC:3335
467401
Macaque
proteasome subunit beta 5
677719
Mouse
MGI:1194513
19173
Rat
RGD:61879
29425
Dog
proteasome subunit beta 5
VGNC:45097
100855659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit beta 5
Macaque
proteasome subunit beta 5
Mouse
Rat
Dog
proteasome subunit beta 5
Publication Statistics
PubMed Score 56.70
PubMed score by year
PubTator Score 46.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title