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Tbio
POU1F1
Pituitary-specific positive transcription factor 1

Protein Summary
Description
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202). This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344265
  • ENSP00000342931
  • ENSG00000064835
  • ENST00000350375
  • ENSP00000263781

Symbol
  • GHF1
  • PIT1
  • PIT1
  • CPHD1
  • GHF-1
  • Pit-1
  • POU1F1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
biological process
0.89
gene perturbation
0.76
tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.22   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.22   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
17.1
1
1
0
1.1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
17.1
0
1.1
10.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 1 homeobox 1
VGNC:12128
470861
Macaque
POU class 1 homeobox 1
719349
Mouse
MGI:97588
18736
Rat
RGD:3367
25517
Dog
POU class 1 homeobox 1
VGNC:44824
403753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 1 homeobox 1
Macaque
POU class 1 homeobox 1
Mouse
Rat
Dog
POU class 1 homeobox 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28069-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
PROP1
Tbio
Family:  TF
Novelty:  0.00510395
Score:  0.924
Data Source:  STRINGDB
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
Score:  0.9
Data Source:  STRINGDB
TSHB
Tbio
Novelty:  0.00194403
Score:  0.889
Data Source:  STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.885
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.852
Data Source:  STRINGDB
HESX1
Tbio
Family:  TF
Novelty:  0.00806405
Score:  0.851
Data Source:  STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.848
Data Source:  STRINGDB
TBX19
Tbio
Family:  TF
Novelty:  0.01599679
Score:  0.847
Data Source:  STRINGDB
CGA
Tbio
Novelty:  0.00394017
Score:  0.817
Data Source:  STRINGDB
ESX1
Tbio
Family:  TF
Novelty:  0.00330753
Score:  0.804
Data Source:  STRINGDB
Publication Statistics
PubMed Score  217.22

PubMed score by year
PubTator Score  422.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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