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Tbio
HLA-DMB
HLA class II histocompatibility antigen, DM beta chain

Protein Summary
Description
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383231
  • ENSP00000372718
  • ENSG00000241674
  • ENST00000395312
  • ENSP00000378723
  • ENSG00000242092
  • ENST00000412948
  • ENSP00000413471
  • ENSG00000241296
  • ENST00000418107
  • ENSP00000398890
  • ENSG00000242574
  • ENST00000424822
  • ENSP00000414817
  • ENSG00000234154
  • ENST00000428420
  • ENSP00000393646
  • ENSG00000239329
  • ENST00000440078
  • ENSP00000411321
  • ENSG00000226264
  • ENST00000450897
  • ENSP00000408453
  • ENSG00000242386

Symbol
  • DMB
  • RING7
  • RING7
  • D6S221E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
phenotype
0.8
cellular component
0.71
cell type or tissue
0.68
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.98   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.98   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
74.6
Eczema
1
1
0
1.2
74.6
1
1
0
1.2
74.6
Eczema
1
1
0
1.2
74.6
1
1
0
1.2
74.6
Items per page:
1 – 5 of 32
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
74.6
Eczema
0
1.2
74.6
0
1.2
74.6
Eczema
0
1.2
74.6
0
1.2
74.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DM beta
449592
Mouse
MGI:95922
14999
Horse
HLA class II histocompatibility antigen, DM beta chain
100060996
Pig
MHC class II, DM beta
100135050
Opossum
HLA class II histocompatibility antigen, DM beta chain
100026858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DM beta
Mouse
Horse
HLA class II histocompatibility antigen, DM beta chain
Pig
MHC class II, DM beta
Opossum
HLA class II histocompatibility antigen, DM beta chain
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28068-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (177)
1 – 10 of 177
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.998623601
p_ni: 0.000133386
p_wrong: 0.001243013
Score: 0.307
Data Source: BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
p_int: 0.998524208
p_ni: 0.001148806
p_wrong: 0.000326987
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
AP3M1
Tbio
Novelty: 0.5036622
p_int: 0.82280061
p_ni: 0.17719939
Score: 0.211
Data Source: BioPlex,STRINGDB
HLA-DMA
Tbio
Novelty: 0.00405566
Score: 0.999
Data Source: Reactome,STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.985
Data Source: Reactome,STRINGDB
HLA-DPA1
Tbio
Novelty: 0.01080446
Score: 0.981
Data Source: Reactome,STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.979
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.979
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.979
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.98

PubMed score by year
PubTator Score  20.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer