Tbio HLA-DMB HLA class II histocompatibility antigen, DM beta chain

Protein Summary

Description

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28068
• O77936
• Q13012
• Q29751
• Q58ZE2
• Q5SNZ8
• Q5STC4
• Q9XRX2

Gene Name

• HLA-DMB

Ensembl ID

• ENST00000383231
• ENSP00000372718
• ENSG00000241674
• ENST00000395312
• ENSP00000378723
• ENSG00000242092
• ENST00000412948
• ENSP00000413471
• ENSG00000241296
• ENST00000418107
• ENSP00000398890
• ENSG00000242574
• ENST00000424822
• ENSP00000414817
• ENSG00000234154
• ENST00000428420
• ENSP00000393646
• ENSG00000239329
• ENST00000440078
• ENSP00000411321
• ENSG00000226264
• ENST00000450897
• ENSP00000408453
• ENSG00000242386

Symbol

• DMB
• RING7
• RING7
• D6S221E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
phenotype	0.8
cellular component	0.71
cell type or tissue	0.68
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Defense/immunity Protein / Major Histocompatibility Complex Antigen / Hla Class Ii Histocompatibility Antigen, Dm Beta Chain

DTO Classes

Protein / Immune Response / Major Histocompatibility Complex Antigen / Hla Class Ii Histocompatibility Antigen, Dm Beta Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.42   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.42   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0