Tbio HLA-DMA HLA class II histocompatibility antigen, DM alpha chain

Protein Summary

Description

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28067
• Q29639
• Q29640

Gene Name

• HLA-DMA

Ensembl ID

• ENST00000374843
• ENSP00000363976
• ENSG00000204257
• ENST00000383230
• ENSP00000372717
• ENSG00000243215
• ENST00000434337
• ENSP00000407198
• ENSG00000242361
• ENST00000441375
• ENSP00000410591
• ENSG00000239463
• ENST00000450601
• ENSP00000392842
• ENSG00000242685
• ENST00000452615
• ENSP00000395349
• ENSG00000243189
• ENST00000453490
• ENSP00000404018
• ENSG00000243719

Symbol

• DMA
• RING6
• DMA
• HLADM
• RING6
• D6S222E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.94
gene perturbation	0.8
phenotype	0.77
disease	0.73
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Defense/immunity Protein / Major Histocompatibility Complex Antigen / Hla Class Ii Histocompatibility Antigen, Dm Alpha Chain

DTO Classes

Protein / Immune Response / Major Histocompatibility Complex Antigen / Hla Class Ii Histocompatibility Antigen, Dm Alpha Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.9   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.9   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0