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Tbio
HLA-DMA
HLA class II histocompatibility antigen, DM alpha chain

Protein Summary
Description
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane doma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374843
  • ENSP00000363976
  • ENSG00000204257
  • ENST00000383230
  • ENSP00000372717
  • ENSG00000243215
  • ENST00000434337
  • ENSP00000407198
  • ENSG00000242361
  • ENST00000441375
  • ENSP00000410591
  • ENSG00000239463
  • ENST00000450601
  • ENSP00000392842
  • ENSG00000242685
  • ENST00000452615
  • ENSP00000395349
  • ENSG00000243189
  • ENST00000453490
  • ENSP00000404018
  • ENSG00000243719

Symbol
  • DMA
  • RING6
  • DMA
  • HLADM
  • RING6
  • D6S222E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.94
gene perturbation
0.8
phenotype
0.77
disease
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.22   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.22   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
58.6
C-reactive protein measurement
1
1
1
58.6
C-reactive protein measurement
1
1
1
58.6
C-reactive protein measurement
1
1
1
58.6
C-reactive protein measurement
1
1
1
58.6
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
58.6
C-reactive protein measurement
1
58.6
C-reactive protein measurement
1
58.6
C-reactive protein measurement
1
58.6
C-reactive protein measurement
1
58.6
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (187)
1 – 10 of 187
HLA-DMB
Tbio
Novelty: 0.02289537
Score: 0.999
Data Source: Reactome,STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tchem
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  251.22

PubMed score by year
PubTator Score  102.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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