HLA-DMA
HLA class II histocompatibility antigen, DM alpha chain
Protein Summary
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane doma ...more
- ENST00000374843
- ENSP00000363976
- ENSG00000204257
- ENST00000383230
- ENSP00000372717
- ENSG00000243215
- ENST00000434337
- ENSP00000407198
- ENSG00000242361
- ENST00000441375
- ENSP00000410591
- ENSG00000239463
- ENST00000450601
- ENSP00000392842
- ENSG00000242685
- ENST00000452615
- ENSP00000395349
- ENSG00000243189
- ENST00000453490
- ENSP00000404018
- ENSG00000243719
- DMA
- RING6
- DMA
- HLADM
- RING6
- D6S222E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.94 | ||
gene perturbation | 0.8 | ||
phenotype | 0.77 | ||
disease | 0.73 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 253.41 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 360 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 253.41 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 360 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (187)
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
JAK1
JAK2
Pathways (31)
Reactome (3)
KEGG (24)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | MHC class II antigen presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
MHC class II antigen presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (7)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (155)
Items per page:
1 – 5 of 155
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.4 | 93.2 | ||||||
2 | 2 | 0 | 1.4 | 93.2 | ||||||
2 | 2 | 0 | 1.4 | 93.2 | ||||||
2 | 2 | 0 | 1.4 | 93.2 | ||||||
2 | 2 | 0 | 1.4 | 93.2 | ||||||
Items per page:
1 – 5 of 155
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 93.2 | |||||
0 | 1.4 | 93.2 | |||||
0 | 1.4 | 93.2 | |||||
0 | 1.4 | 93.2 | |||||
0 | 1.4 | 93.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:95921 | 14998 | ||||||
Dog | major histocompatibility complex, class II, DM alpha | 481732 | ||||||
Pig | SLA-DM alpha chain | 445528 | ||||||
Xenopus | major histocompatibility complex class II alpha chain precursor | XB-GENE-481445 | 100495336 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | major histocompatibility complex, class II, DM alpha | |||||
Pig | SLA-DM alpha chain | |||||
Xenopus | major histocompatibility complex class II alpha chain precursor | |||||
Publication Statistics
PubMed Score 253.41
PubMed score by year
PubTator Score 102.89
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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