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Tbio
PSMA5
Proteasome subunit alpha type-5

Protein Summary
Description
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271308
  • ENSP00000271308
  • ENSG00000143106
  • ENST00000538610
  • ENSP00000440618

Symbol
  • PSC5
  • ZETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
biological process
0.98
interacting protein
0.98
ligand (protein) perturbation
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (442)
PSMG4
Tdark
Novelty:  0.05339077
p_int:  0.999999698
p_ni:  3.02e-7
Score:  0.151
Data Source:  BioPlex,STRINGDB
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.9999993
p_ni:  7e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.999998896
p_ni:  0.000001104
Score:  0.99
Data Source:  BioPlex,STRINGDB
PSMG1
Tbio
Novelty:  0.08175356
p_int:  0.999997997
p_ni:  0.000002003
Score:  0.455
Data Source:  BioPlex,STRINGDB
PSME2
Tbio
Novelty:  0.02624268
p_int:  0.999993148
p_ni:  0.000006852
Score:  0.994
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.999993026
p_ni:  0.000006973
Score:  0.329
Data Source:  BioPlex,STRINGDB
POMP
Tbio
Novelty:  0.01885028
p_int:  0.99999271
p_ni:  0.00000729
Score:  0.991
Data Source:  BioPlex,STRINGDB
AKIRIN1
Tbio
Novelty:  0.16318877
p_int:  0.99997923
p_ni:  0.000001175
p_wrong:  0.000019595
Data Source:  BioPlex
PSMF1
Tbio
Novelty:  0.0364376
p_int:  0.999968214
p_ni:  0.000031786
Score:  0.924
Data Source:  BioPlex,STRINGDB
PSMA7
Tbio
Family:  Enzyme
Novelty:  0.01385043
p_int:  0.999885348
p_ni:  0.000114653
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (156)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
10
10
97.8
low density lipoprotein cholesterol measurement
2
9
10
95.8
glomerular filtration rate
5
5
4
7.9
90.5
total cholesterol measurement
1
5
5
90.4
self reported educational attainment
4
4
3
6.3
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
10
97.8
low density lipoprotein cholesterol measurement
10
95.8
glomerular filtration rate
4
7.9
90.5
total cholesterol measurement
5
90.4
self reported educational attainment
3
6.3
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit alpha 5
VGNC:48990
469795
Macaque
proteasome subunit alpha 5
698435
Mouse
MGI:1347009
26442
Rat
RGD:61848
29672
Dog
proteasome subunit alpha 5
VGNC:54060
100856348
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit alpha 5
Macaque
proteasome subunit alpha 5
Mouse
Rat
Dog
proteasome subunit alpha 5
Publication Statistics
PubMed Score 23.78
PubMed score by year
PubTator Score 11.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title