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Tchem
PSMB9
Proteasome subunit beta type-9

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374859
  • ENSP00000363993
  • ENSG00000240065
  • ENST00000383114
  • ENSP00000372595
  • ENSG00000240118
  • ENST00000383234
  • ENSP00000372721
  • ENSG00000243594
  • ENST00000422729
  • ENSP00000407233
  • ENSG00000243067
  • ENST00000427870
  • ENSP00000412027
  • ENSG00000242711
  • ENST00000434471
  • ENSP00000393744
  • ENSG00000243958
  • ENST00000444284
  • ENSP00000396813
  • ENSG00000239836
  • ENST00000453059
  • ENSP00000407810
  • ENSG00000240508

Symbol
  • LMP2
  • PSMB6i
  • RING12
  • LMP2
  • PRAAS3
  • PSMB6i
  • RING12
  • beta1i
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.99
biological process
0.98
PubMedID
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.47   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.47   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (155)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (396)
1 – 10 of 396
PSMA8
Tdark
Family: Enzyme
Novelty: 0.85714286
p_int: 0.999999992
p_ni: 7e-9
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
PSMG2
Tbio
Novelty: 0.07196402
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.925
Data Source: BioPlex,STRINGDB
PSMB3
Tdark
Family: Enzyme
Novelty: 0.2736908
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
POMP
Tbio
Novelty: 0.02340181
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.955
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.13674668
p_int: 0.999999889
p_ni: 1.11e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
PSME2
Tbio
Novelty: 0.03427537
p_int: 0.999999889
p_ni: 1.11e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
PSME4
Tbio
Novelty: 0.0226821
p_int: 0.999999186
p_ni: 8.14e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
PSME1
Tbio
Novelty: 0.02035196
p_int: 0.999998506
p_ni: 0.000001494
Score: 0.994
Data Source: BioPlex,STRINGDB
CKM
Tbio
Family: Kinase
Novelty: 0.00329483
p_int: 0.999973821
p_ni: 0.000019674
p_wrong: 0.000006505
Data Source: BioPlex
PSMG1
Tbio
Novelty: 0.11758926
p_int: 0.999958767
p_ni: 0.000041233
Score: 0.869
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  396.47

PubMed score by year
PubTator Score  304.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer