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Tchem
PSMB9
Proteasome subunit beta type-9

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374859
  • ENSP00000363993
  • ENSG00000240065
  • ENST00000383114
  • ENSP00000372595
  • ENSG00000240118
  • ENST00000383234
  • ENSP00000372721
  • ENSG00000243594
  • ENST00000422729
  • ENSP00000407233
  • ENSG00000243067
  • ENST00000427870
  • ENSP00000412027
  • ENSG00000242711
  • ENST00000434471
  • ENSP00000393744
  • ENSG00000243958
  • ENST00000444284
  • ENSP00000396813
  • ENSG00000239836
  • ENST00000453059
  • ENSP00000407810
  • ENSG00000240508

Symbol
  • LMP2
  • PSMB6i
  • RING12
  • LMP2
  • PRAAS3
  • PSMB6i
  • RING12
  • beta1i
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.99
biological process
0.98
PubMedID
0.91
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.04   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.04   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (70)
CHEMBL4297468
Rendered image for CHEMBL4297468
CHEMBL4749207
Rendered image for CHEMBL4749207
Delanzomib
Rendered image for Delanzomib
CHEMBL4465456
Rendered image for CHEMBL4465456
CHEMBL4787081
Rendered image for CHEMBL4787081
CHEMBL4781914
Rendered image for CHEMBL4781914
CHEMBL4877708
Rendered image for CHEMBL4877708
Halicyclamine B
Rendered image for Halicyclamine B
CHEMBL4872258,CHEMBL4863207
Rendered image for CHEMBL4872258,CHEMBL4863207
CHEMBL4749043
Rendered image for CHEMBL4749043
Protein-Protein Interactions (396)
PSMA8
Tdark
Family:  Enzyme
Novelty:  0.83041547
p_int:  0.999999992
p_ni:  7e-9
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.925
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
POMP
Tbio
Novelty:  0.01885028
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.955
Data Source:  BioPlex,STRINGDB
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.999999889
p_ni:  1.11e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
PSME2
Tbio
Novelty:  0.02624268
p_int:  0.999999889
p_ni:  1.11e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.999999186
p_ni:  8.14e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
PSME1
Tbio
Novelty:  0.01258149
p_int:  0.999998506
p_ni:  0.000001494
Score:  0.994
Data Source:  BioPlex,STRINGDB
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999973821
p_ni:  0.000019674
p_wrong:  0.000006505
Data Source:  BioPlex
PSMG1
Tbio
Novelty:  0.08175356
p_int:  0.999958767
p_ni:  0.000041233
Score:  0.869
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (155)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (400)
Items per page:
1 – 5 of 400
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
2
93.9
3
1
0
2
93.9
3
1
0
2
93.9
3
1
0
2
93.9
3
1
0
2
93.9
Items per page:
1 – 5 of 400
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
93.9
0
2
93.9
0
2
93.9
0
2
93.9
0
2
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
proteasome subunit beta 9
716980
Mouse
MGI:1346526
16912
Rat
RGD:3427
24967
Dog
proteasome subunit beta 9
VGNC:45100
474867
Horse
proteasome subunit beta 9
VGNC:21948
100060885
Species
Name
OMA
EggNOG
Inparanoid
Macaque
proteasome subunit beta 9
Mouse
Rat
Dog
proteasome subunit beta 9
Horse
proteasome subunit beta 9
Publication Statistics
PubMed Score 731.04
PubMed score by year
PubTator Score 304.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title