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Tclin
PSMB8
Proteasome subunit beta type-8

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374881
  • ENSP00000364015
  • ENSG00000204264
  • ENST00000374882
  • ENSP00000364016
  • ENST00000383236
  • ENSP00000372723
  • ENSG00000206298
  • ENST00000383238
  • ENSP00000372725
  • ENST00000416134
  • ENSP00000397057
  • ENSG00000235715
  • ENST00000416564
  • ENSP00000408825
  • ENSG00000226201
  • ENST00000421445
  • ENSP00000402406
  • ENSG00000236443
  • ENST00000429645
  • ENSP00000394155
  • ENST00000435978
  • ENSP00000414731
  • ENSG00000231631
  • ENST00000436627
  • ENSP00000392693
  • ENSG00000230669
  • ENST00000438442
  • ENSP00000404585
  • ENST00000441960
  • ENSP00000407539
  • ENSG00000230034
  • ENST00000452573
  • ENSP00000412618
  • ENST00000455660
  • ENSP00000406797
  • ENST00000457261
  • ENSP00000414770

Symbol
  • LMP7
  • PSMB5i
  • RING10
  • Y2
  • JMP
  • ALDD
  • LMP7
  • NKJO
  • D6S216
  • PRAAS1
  • PSMB5i
  • RING10
  • D6S216E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
PubMedID
0.97
gene perturbation
0.96
transcription factor perturbation
0.91
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 572.75   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 572.75   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bortezomib
Rendered image for bortezomib
GWAS Traits (320)
Items per page:
1 – 5 of 320
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
5
0
1.1
90
1
5
0
1.1
90
Eczema
1
5
0
1.1
90
Eczema
1
5
0
1.1
90
1
5
0
1.1
90
Items per page:
1 – 5 of 320
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90
0
1.1
90
Eczema
0
1.1
90
Eczema
0
1.1
90
0
1.1
90
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1346527
16913
Rat
RGD:3426
24968
Dog
proteasome subunit beta 8
VGNC:45099
474865
Horse
proteasome subunit beta 8
VGNC:21947
100052481
Cow
proteasome subunit beta 8
VGNC:33452
282013
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proteasome subunit beta 8
Horse
proteasome subunit beta 8
Cow
proteasome subunit beta 8
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28062-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (158)
ABC transporter disorders (R-HSA-5619084)

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Items per page:
1 – 5 of 150
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (403)
1 – 10 of 403
PSMD8
Tbio
Family:  Enzyme
Novelty:  0.03053455
Score:  0.999
Data Source:  STRINGDB
PSMA4
Tbio
Family:  Enzyme
Novelty:  0.04515869
Score:  0.999
Data Source:  STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
Score:  0.999
Data Source:  STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
Score:  0.999
Data Source:  STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
Score:  0.999
Data Source:  STRINGDB
PSMC6
Tbio
Family:  Enzyme
Novelty:  0.00168013
Score:  0.999
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.999
Data Source:  STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
Score:  0.999
Data Source:  STRINGDB
PSMA6
Tbio
Family:  Enzyme
Novelty:  0.01525994
Score:  0.999
Data Source:  STRINGDB
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  572.75

PubMed score by year
PubTator Score  153.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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