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Tclin
PSMB8
Proteasome subunit beta type-8

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374881
  • ENSP00000364015
  • ENSG00000204264
  • ENST00000374882
  • ENSP00000364016
  • ENST00000383236
  • ENSP00000372723
  • ENSG00000206298
  • ENST00000383238
  • ENSP00000372725
  • ENST00000416134
  • ENSP00000397057
  • ENSG00000235715
  • ENST00000416564
  • ENSP00000408825
  • ENSG00000226201
  • ENST00000421445
  • ENSP00000402406
  • ENSG00000236443
  • ENST00000429645
  • ENSP00000394155
  • ENST00000435978
  • ENSP00000414731
  • ENSG00000231631
  • ENST00000436627
  • ENSP00000392693
  • ENSG00000230669
  • ENST00000438442
  • ENSP00000404585
  • ENST00000441960
  • ENSP00000407539
  • ENSG00000230034
  • ENST00000452573
  • ENSP00000412618
  • ENST00000455660
  • ENSP00000406797
  • ENST00000457261
  • ENSP00000414770

Symbol
  • LMP7
  • PSMB5i
  • RING10
  • Y2
  • JMP
  • ALDD
  • LMP7
  • NKJO
  • D6S216
  • PRAAS1
  • PSMB5i
  • RING10
  • D6S216E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
PubMedID
0.97
gene perturbation
0.96
transcription factor perturbation
0.91
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.22   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.22   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bortezomib
chemical structure image
Active Ligands (33)
1 – 10 of 33
CHEMBL3319481
chemical structure image
CHEMBL3319483,CHEMBL3319482
chemical structure image
CHEMBL3319592,CHEMBL3319591
chemical structure image
CHEMBL3319579,CHEMBL3319584
chemical structure image
CHEMBL3237873
chemical structure image
CHEMBL3237863
chemical structure image
CHEMBL2103884
chemical structure image
CHEMBL2336253
chemical structure image
CHEMBL3265177
chemical structure image
CHEMBL3319577
chemical structure image
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (158)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 150
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (403)
1 – 10 of 403
PSMD8
Tbio
Family: Enzyme
Novelty: 0.03552744
Score: 0.999
Data Source: STRINGDB
PSMA4
Tbio
Family: Enzyme
Novelty: 0.08982587
Score: 0.999
Data Source: STRINGDB
PSMB9
Tchem
Family: Enzyme
Novelty: 0.00259191
Score: 0.999
Data Source: STRINGDB
PSMA5
Tbio
Family: Enzyme
Novelty: 0.05889678
Score: 0.999
Data Source: STRINGDB
PSMC4
Tbio
Family: Enzyme
Novelty: 0.02568601
Score: 0.999
Data Source: STRINGDB
PSMC6
Tbio
Family: Enzyme
Novelty: 0.00224574
Score: 0.999
Data Source: STRINGDB
PSMB3
Tdark
Family: Enzyme
Novelty: 0.2736908
Score: 0.999
Data Source: STRINGDB
PSMD6
Tbio
Family: Enzyme
Novelty: 0.04148078
Score: 0.999
Data Source: STRINGDB
PSMA6
Tbio
Family: Enzyme
Novelty: 0.00156019
Score: 0.999
Data Source: STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.15790562
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  347.22

PubMed score by year
PubTator Score  153.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer