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Tclin
PSMB8
Proteasome subunit beta type-8

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374881
  • ENSP00000364015
  • ENSG00000204264
  • ENST00000374882
  • ENSP00000364016
  • ENST00000383236
  • ENSP00000372723
  • ENSG00000206298
  • ENST00000383238
  • ENSP00000372725
  • ENST00000416134
  • ENSP00000397057
  • ENSG00000235715
  • ENST00000416564
  • ENSP00000408825
  • ENSG00000226201
  • ENST00000421445
  • ENSP00000402406
  • ENSG00000236443
  • ENST00000429645
  • ENSP00000394155
  • ENST00000435978
  • ENSP00000414731
  • ENSG00000231631
  • ENST00000436627
  • ENSP00000392693
  • ENSG00000230669
  • ENST00000438442
  • ENSP00000404585
  • ENST00000441960
  • ENSP00000407539
  • ENSG00000230034
  • ENST00000452573
  • ENSP00000412618
  • ENST00000455660
  • ENSP00000406797
  • ENST00000457261
  • ENSP00000414770

Symbol
  • LMP7
  • PSMB5i
  • RING10
  • Y2
  • JMP
  • ALDD
  • LMP7
  • NKJO
  • D6S216
  • PRAAS1
  • PSMB5i
  • RING10
  • D6S216E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
PubMedID
0.97
gene perturbation
0.96
transcription factor perturbation
0.91
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 534.67   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 534.67   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 181
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1