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Tchem
AOAH
Acyloxyacyl hydrolase

Protein Summary
Description
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145, PubMed:29343645). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612871
  • ENSP00000484305
  • ENSG00000136250
  • ENST00000617537
  • ENSP00000483783
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
trait
0.75
tissue sample
0.65
PubMedID
0.6
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.63   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.63   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (40)
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.715
Data Source:  STRINGDB
IGSF6
Tbio
Novelty:  0.05015035
Score:  0.673
Data Source:  STRINGDB
CDNF
Tbio
Novelty:  0.02100131
Score:  0.633
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.626
Data Source:  STRINGDB
ATF6
Tbio
Family:  TF
Novelty:  0.00149266
Score:  0.626
Data Source:  STRINGDB
MANF
Tbio
Novelty:  0.00586461
Score:  0.622
Data Source:  STRINGDB
CD14
Tbio
Novelty:  0.00872424
Score:  0.597
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.587
Data Source:  STRINGDB
FGL2
Tbio
Novelty:  0.01108434
Score:  0.581
Data Source:  STRINGDB
FGR
Tchem
Family:  Kinase
Novelty:  0.00262848
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
77.1
1
1
1
29
1
1
0
1.2
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
77.1
1
29
0
1.2
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
acyloxyacyl hydrolase
706291
Mouse
MGI:1350928
27052
Rat
RGD:1560514
498757
Dog
acyloxyacyl hydrolase
VGNC:37946
482402
Horse
acyloxyacyl hydrolase
VGNC:15368
100055508
Species
Name
OMA
EggNOG
Inparanoid
Macaque
acyloxyacyl hydrolase
Mouse
Rat
Dog
acyloxyacyl hydrolase
Horse
acyloxyacyl hydrolase
Publication Statistics
PubMed Score 45.63
PubMed score by year
PubTator Score 18.85
PubTator score by year
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Related Publications
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PMID
Year
Title