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Tchem
ITPKB
Inositol-trisphosphate 3-kinase B

Protein Classes
Protein Summary
Description
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272117
  • ENSP00000272117
  • ENSG00000143772
  • ENST00000366784
  • ENSP00000355748
  • ENST00000429204
  • ENSP00000411152

Symbol
  • IP3K
  • IP3KB
  • PIG37
  • IP3K-B
  • IP3-3KB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.93
PubMedID
0.84
cell type or tissue
0.79
cell line
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.35   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.35   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GNF362
chemical structure image
Pathways (12)
Inositol phosphate metabolism (R-HSA-1483249)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (522)
1 – 10 of 522
PTEN
Tchem
Family: Enzyme
Novelty: 0.00017995
Score: 0.965
Data Source: STRINGDB
IPMK
Tbio
Family: Kinase
Novelty: 0.02115444
Score: 0.963
Data Source: STRINGDB
INPP5D
Tbio
Family: Enzyme
Novelty: 0.00819089
Score: 0.945
Data Source: STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03832271
Score: 0.944
Data Source: STRINGDB
ITPK1
Tbio
Family: Kinase
Novelty: 0.03799195
Score: 0.942
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00125418
Score: 0.939
Data Source: STRINGDB
MINPP1
Tbio
Family: Enzyme
Novelty: 0.03074783
Score: 0.933
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00370802
Score: 0.933
Data Source: STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00821462
Score: 0.928
Data Source: STRINGDB
PLCD4
Tbio
Family: Enzyme
Novelty: 0.06740018
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.35

PubMed score by year
PubTator Score  27.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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