You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha

Protein Summary
Description
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320694
  • ENSP00000323512
  • ENSG00000145675
  • ENST00000336483
  • ENSP00000338554
  • ENST00000521381
  • ENSP00000428056
  • ENST00000521657
  • ENSP00000429277
  • ENST00000523872
  • ENSP00000430098

Symbol
  • GRB1
  • p85
  • AGM7
  • GRB1
  • IMD36
  • p85-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
transcription factor perturbation
1
kinase
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.52   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 994   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.52   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 994   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (676)
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
p_int:  0.965590096
p_ni:  0.034409904
Score:  0.983
Data Source:  BioPlex,STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.959155169
p_ni:  0.040844831
Score:  0.55
Data Source:  BioPlex,STRINGDB
PCBP1
Tbio
Novelty:  0.00906713
p_int:  0.959080933
p_ni:  0.040919067
Score:  0.238
Data Source:  BioPlex,STRINGDB
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.944480495
p_ni:  0.055519505
Score:  0.676
Data Source:  BioPlex,STRINGDB
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
p_int:  0.94430652
p_ni:  0.05569348
Score:  0.982
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.884561221
p_ni:  0.115438779
Data Source:  BioPlex
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.827620269
p_ni:  0.172379731
Data Source:  BioPlex
SNX32
Tdark
Novelty:  0.66136036
p_int:  0.827464286
p_ni:  0.172535714
Score:  0.161
Data Source:  BioPlex,STRINGDB
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.808972554
p_ni:  0.191027446
Score:  0.379
Data Source:  BioPlex,STRINGDB
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  0.799261238
p_ni:  0.200738762
Score:  0.512
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (57)
Explore Nearest Tclin Targets
Pathways (376)
Activated NTRK2 signals through PI3K (R-HSA-9028335)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 114
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through PI3K
Reactome
Activated NTRK3 signals through PI3K
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through PI3K
Activated NTRK3 signals through PI3K
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (72)
Find Similar Targets
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
4
92.1
mean corpuscular hemoglobin concentration
1
1
1
81.5
mean reticulocyte volume
1
1
1
77.1
lymphocyte count
2
2
2
73.2
body height
1
1
1
69.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
92.1
mean corpuscular hemoglobin concentration
1
81.5
mean reticulocyte volume
1
77.1
lymphocyte count
2
73.2
body height
1
69.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphoinositide-3-kinase regulatory subunit 1
698996
Mouse
MGI:97583
18708
Rat
RGD:3329
25513
Dog
phosphoinositide-3-kinase regulatory subunit 1
VGNC:44560
487235
Horse
phosphoinositide-3-kinase regulatory subunit 1
VGNC:21451
100050227
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphoinositide-3-kinase regulatory subunit 1
Mouse
Rat
Dog
phosphoinositide-3-kinase regulatory subunit 1
Horse
phosphoinositide-3-kinase regulatory subunit 1
Publication Statistics
PubMed Score 561.52
PubMed score by year
PubTator Score 415.38
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title