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Tbio
IL1R2
Interleukin-1 receptor type 2

Protein Summary
Description
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332549
  • ENSP00000330959
  • ENSG00000115590
  • ENST00000393414
  • ENSP00000377066
  • ENST00000441002
  • ENSP00000414611

Symbol
  • IL1RB
  • IL1RB
  • CD121b
  • IL1R2c
  • CDw121b
  • IL-1R-2
  • IL-1RT2
  • IL-1RT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
protein domain
0.92
disease
0.79
small molecule perturbation
0.71
transcription factor perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.58   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 566   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.58   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor type 2
VGNC:10291
470455
Macaque
interleukin 1 receptor type 2
711638
Mouse
MGI:96546
16178
Rat
RGD:621147
117022
Dog
interleukin 1 receptor type 2
VGNC:41959
481330
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor type 2
Macaque
interleukin 1 receptor type 2
Mouse
Rat
Dog
interleukin 1 receptor type 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Interleukin-10 signaling
Protein-Protein Interactions (107)
1 – 10 of 107
EXOC6B
Tbio
Novelty: 0.11301293
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.551
Data Source: BioPlex,STRINGDB
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.999998727
p_ni: 0.000001273
Data Source: BioPlex
EXOC6
Tbio
Novelty: 0.01886811
p_int: 0.999994882
p_ni: 0.000005116
p_wrong: 1e-9
Score: 0.594
Data Source: BioPlex,STRINGDB
NUDT16
Tbio
Novelty: 0.06032864
p_int: 0.999988601
p_ni: 0.000011399
Score: 0.188
Data Source: BioPlex,STRINGDB
EXOC5
Tbio
Novelty: 0.02200205
p_int: 0.999972316
p_ni: 0.000027684
Score: 0.544
Data Source: BioPlex,STRINGDB
EXOC7
Tbio
Novelty: 0.00852508
p_int: 0.999972277
p_ni: 0.000027723
Score: 0.452
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.999918156
p_ni: 0.000081844
Score: 0.194
Data Source: BioPlex,STRINGDB
TRMU
Tbio
Family: Enzyme
Novelty: 0.01615197
p_int: 0.999910981
p_ni: 0.000037765
p_wrong: 0.000051254
Data Source: BioPlex
EXOC2
Tbio
Novelty: 0.01434464
p_int: 0.999864646
p_ni: 0.000135354
Score: 0.764
Data Source: BioPlex,STRINGDB
LONP2
Tbio
Family: Enzyme
Novelty: 0.04499043
p_int: 0.999811161
p_ni: 0.000188831
p_wrong: 8e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  110.58

PubMed score by year
PubTator Score  116.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer