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Tbio
CANX
Calnexin

Protein Summary
Description
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247461
  • ENSP00000247461
  • ENSG00000127022
  • ENST00000452673
  • ENSP00000391646
  • ENST00000504734
  • ENSP00000424063
  • ENST00000638425
  • ENSP00000492372
  • ENSG00000283777
  • ENST00000638706
  • ENSP00000492868
  • ENST00000639938
  • ENSP00000491760

Symbol
  • CNX
  • P90
  • IP90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
interacting protein
1
virus perturbation
1
transcription factor perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 714.05   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 1012   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 714.05   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 1012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (27)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
Assembly of Viral Components at the Budding Site
Reactome
Calnexin/calreticulin cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
Assembly of Viral Components at the Budding Site
Calnexin/calreticulin cycle
Gene Ontology Terms (37)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (544)
1 – 10 of 544
CD1E
Tbio
Novelty: 0.00231902
p_int: 0.996536101
p_ni: 0.003463899
Score: 0.18
Data Source: BioPlex,STRINGDB
CD1A
Tbio
Novelty: 0.00133941
p_int: 0.991025366
p_ni: 0.008974635
Data Source: BioPlex
P2RX2
Tchem
Family: IC
Novelty: 0.00308345
p_int: 0.988062811
p_ni: 0.011937189
Data Source: BioPlex
CLEC2D
Tbio
Novelty: 0.03470529
p_int: 0.985464211
p_ni: 0.014535789
Data Source: BioPlex
BRINP2
Tdark
Novelty: 1.14049587
p_int: 0.980406408
p_ni: 0.019593592
Score: 0.172
Data Source: BioPlex,STRINGDB
GXYLT1
Tdark
Family: Enzyme
Novelty: 0.93745897
p_int: 0.979873865
p_ni: 0.020126135
Data Source: BioPlex
CHST15
Tbio
Family: Enzyme
Novelty: 0.02757155
p_int: 0.97975032
p_ni: 0.02024968
Score: 0.181
Data Source: BioPlex,STRINGDB
NRROS
Tbio
Novelty: 0.15009747
p_int: 0.977306423
p_ni: 0.022693577
Data Source: BioPlex
CHST6
Tbio
Family: Enzyme
Novelty: 0.02270215
p_int: 0.977266771
p_ni: 0.022733229
Data Source: BioPlex
OGFOD3
Tdark
Family: Enzyme
Novelty: 0.8
p_int: 0.973596245
p_ni: 0.026403755
Data Source: BioPlex
Publication Statistics
PubMed Score  714.05

PubMed score by year
PubTator Score  450.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer