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Tbio
CANX
Calnexin

Protein Summary
Description
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247461
  • ENSP00000247461
  • ENSG00000127022
  • ENST00000452673
  • ENSP00000391646
  • ENST00000504734
  • ENSP00000424063
  • ENST00000638425
  • ENSP00000492372
  • ENSG00000283777
  • ENST00000638706
  • ENSP00000492868
  • ENST00000639938
  • ENSP00000491760

Symbol
  • CNX
  • P90
  • IP90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
interacting protein
1
virus perturbation
1
transcription factor perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1257.35   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 1012   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1257.35   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 1012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0