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Tclin
PDE4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293683
  • ENSP00000293683
  • ENSG00000065989
  • ENST00000344979
  • ENSP00000341007
  • ENST00000380702
  • ENSP00000370078
  • ENST00000440014
  • ENSP00000394754
  • ENST00000592685
  • ENSP00000468507

Symbol
  • DPDE2
  • PDE4
  • DPDE2
  • PDE46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.95
transcription factor binding site profile
0.93
molecular function
0.9
drug
0.79
PubMedID
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1644.3   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1644.3   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 523
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Approved Drugs (9)
1 – 9 of 9
dipyridamole
Rendered image for dipyridamole
choline theophyllinate
no chemical structure image available
bufylline
no chemical structure image available
flavoxate
Rendered image for flavoxate
theophylline
Rendered image for theophylline
crisaborole
Rendered image for crisaborole
amlexanox
Rendered image for amlexanox
roflumilast
Rendered image for roflumilast
apremilast
Rendered image for apremilast
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
5
6
97.1
total cholesterol measurement
2
4
5
95.9
apolipoprotein B measurement
1
2
2
92.3
6
5
0
1.2
92
2
2
0
1.2
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
97.1
total cholesterol measurement
5
95.9
apolipoprotein B measurement
2
92.3
0
1.2
92
0
1.2
84.1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P27815-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
DARPP-32 events (R-HSA-180024)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Opioid Signalling
Name
Explore in Pharos
Explore in Source
DARPP-32 events
G alpha (i) signalling events
G alpha (s) signalling events
GPCR downstream signalling
Opioid Signalling
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (133)
1 – 10 of 133
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.986902853
p_ni:  1.5e-8
p_wrong:  0.013097132
Score:  0.277
Data Source:  BioPlex,STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
Score:  0.923
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.913
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.909
Data Source:  STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
Score:  0.908
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.905
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.904
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.903
Data Source:  STRINGDB
ADCY7
Tbio
Family:  Enzyme
Novelty:  0.00984562
Score:  0.887
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.886
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1644.30

PubMed score by year
PubTator Score  830.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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