You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CALR
Calreticulin

Protein Summary
Description
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316448
  • ENSP00000320866
  • ENSG00000179218

Symbol
  • CRTC
  • RO
  • CRT
  • SSA
  • cC1qR
  • HEL-S-99n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
molecular function
0.99
biological term
0.98
transcription factor binding site profile
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2188.44   (req: < 5)
Gene RIFs: 316   (req: <= 3)
Antibodies: 991   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2188.44   (req: >= 5)
Gene RIFs: 316   (req: > 3)
Antibodies: 991   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
28.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
28.9
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
ATF6 (ATF6-alpha) activates chaperone genes (R-HSA-381183)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Name
Explore in Pharos
Explore in Source
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Gene Ontology Terms (86)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (389)
1 – 10 of 389
INHA
Tbio
Novelty: 0.00168407
p_int: 0.994813064
p_ni: 0.005186936
Score: 0.513
Data Source: BioPlex,STRINGDB
SFRP4
Tbio
Novelty: 0.00174428
p_int: 0.986165662
p_ni: 0.013834338
Score: 0.228
Data Source: BioPlex,STRINGDB
NTM
Tbio
Novelty: 0.01659865
p_int: 0.906818508
p_ni: 0.093181492
Score: 0.241
Data Source: BioPlex,STRINGDB
CFB
Tchem
Novelty: 0.00102672
p_int: 0.894189774
p_ni: 0.105810226
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.847525508
p_ni: 0.152474492
Data Source: BioPlex
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.83363823
p_ni: 0.16636177
Score: 0.177
Data Source: BioPlex,STRINGDB
CHI3L1
Tbio
Family: Enzyme
Novelty: 0.00119387
p_int: 0.784491705
p_ni: 0.215508295
Score: 0.241
Data Source: BioPlex,STRINGDB
BMP4
Tchem
Novelty: 0.00047387
p_int: 0.758634768
p_ni: 0.241365232
Score: 0.373
Data Source: BioPlex,STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.999
Data Source: STRINGDB
P4HB
Tbio
Family: Enzyme
Novelty: 0.00107905
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  2188.44

PubMed score by year
PubTator Score  1167.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: