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Tchem
DCK
Deoxycytidine kinase

Protein Summary
Description
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286648
  • ENSP00000286648
  • ENSG00000156136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.88
cell type or tissue
0.75
drug
0.7
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 543.84   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 554   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 543.84   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
1
1
57.9
viral load
1
1
1
57.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
57.9
viral load
1
57.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxycytidine kinase
VGNC:587
461273
Macaque
deoxycytidine kinase
705040
Mouse
MGI:102726
13178
Rat
RGD:620667
79127
Dog
deoxycytidine kinase
VGNC:39802
482188
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxycytidine kinase
Macaque
deoxycytidine kinase
Mouse
Rat
Dog
deoxycytidine kinase
Protein Structure (47 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P27707-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 47
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Pyrimidine salvage
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (134)
1 – 10 of 134
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999999988
p_ni: 4e-9
p_wrong: 1e-8
Score: 0.305
Data Source: BioPlex,STRINGDB
ZNF503
Tbio
Novelty: 0.07234099
p_int: 0.999810464
p_ni: 0.000189536
Data Source: BioPlex
IRF2BPL
Tdark
Novelty: 0.05458595
p_int: 0.999251172
p_ni: 0.000476706
p_wrong: 0.000272122
Data Source: BioPlex
DACH1
Tbio
Novelty: 0.00986576
p_int: 0.997459256
p_ni: 0.000124875
p_wrong: 0.002415869
Data Source: BioPlex
ANKRD13A
Tbio
Novelty: 0.61940334
p_int: 0.962380267
p_ni: 0.030586147
p_wrong: 0.007033587
Data Source: BioPlex
CDA
Tchem
Family: Enzyme
Novelty: 0.00280981
Score: 0.986
Data Source: STRINGDB
DCTD
Tbio
Family: Enzyme
Novelty: 0.02275597
Score: 0.98
Data Source: STRINGDB
CMPK1
Tbio
Family: Kinase
Novelty: 0.01478492
Score: 0.969
Data Source: STRINGDB
NT5C2
Tbio
Family: Enzyme
Novelty: 0.00758288
Score: 0.968
Data Source: STRINGDB
PNP
Tclin
Family: Enzyme
Novelty: 0.0019084
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  543.84

PubMed score by year
PubTator Score  403.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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