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Tbio
COL8A1
Collagen alpha-1(VIII) chain

Protein Summary
Description
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261037
  • ENSP00000261037
  • ENSG00000144810
  • ENST00000273342
  • ENSP00000273342

Symbol
  • C3orf7
  • C3orf7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.79
cell type or tissue
0.71
gene perturbation
0.66
disease
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.04   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.04   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
81.7
vital capacity
1
1
1
58
forced expiratory volume
1
1
1
37.7
atrophic macular degeneration
1
1
0
1.1
36
1
1
0
1.1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
81.7
vital capacity
1
58
forced expiratory volume
1
37.7
atrophic macular degeneration
0
1.1
36
0
1.1
36
Pathways (7)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Protein-Protein Interactions (108)
1 – 10 of 108
COL6A3
Tbio
Novelty: 0.00805254
Score: 0.949
Data Source: STRINGDB
COL8A2
Tbio
Novelty: 0.01672103
Score: 0.945
Data Source: STRINGDB
COL6A1
Tbio
Novelty: 0.00644855
Score: 0.937
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.936
Data Source: STRINGDB
COL16A1
Tbio
Novelty: 0.11147945
Score: 0.936
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.933
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.933
Data Source: STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.933
Data Source: STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
Score: 0.931
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.04

PubMed score by year
PubTator Score  18.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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