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Tbio
RPL10
60S ribosomal protein L10

Protein Summary
Description
Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344746
  • ENSP00000341730
  • ENSG00000147403
  • ENST00000369817
  • ENSP00000358832
  • ENST00000424325
  • ENSP00000413436

Symbol
  • DXS648E
  • QM
  • QM
  • L10
  • NOV
  • AUTSX5
  • DXS648
  • MRXS35
  • DXS648E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
virus perturbation
1
kinase perturbation
0.96
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.65   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.65   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
3
91.4
reticulocyte count
2
2
2
89.6
leukocyte count
1
1
1
72.5
sex hormone-binding globulin measurement
3
2
3
57.7
neutrophil count
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
91.4
reticulocyte count
2
89.6
leukocyte count
1
72.5
sex hormone-binding globulin measurement
3
57.7
neutrophil count
1
36.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:105943
110954
Rat
RGD:621178
81764
Horse
ribosomal protein L10
100146244
Cow
ribosomal protein L10
286790
Anole lizard
ribosomal protein L10
100567702
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
ribosomal protein L10
Cow
ribosomal protein L10
Anole lizard
ribosomal protein L10
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P27635-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (377)
1 – 10 of 377
AAMP
Tbio
Novelty:  0.0160792
p_int:  0.979175145
p_ni:  0.020824855
Score:  0.925
Data Source:  BioPlex,STRINGDB
RPLP1
Tbio
Novelty:  0.01471148
Score:  0.999
Data Source:  STRINGDB
RPS19
Tbio
Novelty:  0.00380084
Score:  0.999
Data Source:  STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
Score:  0.999
Data Source:  STRINGDB
RPS21
Tbio
Novelty:  0.00578555
Score:  0.999
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.999
Data Source:  STRINGDB
RPS17
Tbio
Novelty:  0.00942675
Score:  0.999
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.999
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.999
Data Source:  STRINGDB
RPS9
Tbio
Novelty:  0.01329701
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  75.65

PubMed score by year
PubTator Score  56.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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