Tbio CERS1 Ceramide synthase 1

Protein Summary

Description

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P27544
• CerS1

Gene Name

• CERS1

Ensembl ID

• ENST00000429504
• ENSP00000389044
• ENSG00000223802
• ENST00000623882
• ENSP00000485308

Symbol

• LAG1
• LASS1
• UOG1
• EPM8
• GDF1
• LAG1
• UOG1
• GDF-1
• LASS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.71
cellular component	0.7
biological process	0.67
tissue sample	0.67
microRNA	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0