Tbio ARNT Aryl hydrocarbon receptor nuclear translocator

Protein Summary

Description

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• P27540
• B2R9H1
• C4AMA1
• F8WAP6
• Q59ED4
• Q5QP39
• Q8NDC7
• ARNT protein

Gene Name

• ARNT

Ensembl ID

• ENST00000354396
• ENSP00000346372
• ENSG00000143437
• ENST00000358595
• ENSP00000351407
• ENST00000505755
• ENSP00000427571
• ENST00000515192
• ENSP00000423851

Symbol

• BHLHE2
• HIF1B
• TANGO
• bHLHe2
• HIF1BETA
• HIF-1beta
• HIF1-beta
• HIF-1-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
molecular function	0.93
chemical	0.92
kinase perturbation	0.88
hub protein	0.82

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Aryl Hydrocarbon Receptor Nuclear Translocator

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Aryl Hydrocarbon Receptor Nuclear Translocator

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.48   (req: < 5)

Gene RIFs: 114   (req: <= 3)

Antibodies: 602   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.48   (req: >= 5)

Gene RIFs: 114   (req: > 3)

Antibodies: 602   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0