You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
DPP4
Dipeptidyl peptidase 4

Protein Summary
Description
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360534
  • ENSP00000353731
  • ENSG00000197635

Symbol
  • ADCP2
  • CD26
  • CD26
  • ADABP
  • ADCP2
  • DPPIV
  • TP103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
drug
1
PubMedID
0.99
cellular component
0.98
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6275.42   (req: < 5)
Gene RIFs: 359   (req: <= 3)
Antibodies: 1632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6275.42   (req: >= 5)
Gene RIFs: 359   (req: > 3)
Antibodies: 1632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3147
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Approved Drugs (11)
1 – 10 of 11
teneligliptin
chemical structure image
anagliptin
chemical structure image
vildagliptin
chemical structure image
saxagliptin
chemical structure image
linagliptin
chemical structure image
omarigliptin
chemical structure image
trelagliptin
chemical structure image
gemigliptin
chemical structure image
sitagliptin
chemical structure image
alogliptin
chemical structure image
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
96
intelligence
4
5
3
7.2
95.7
cortical surface area measurement
1
2
0
9.3
85.2
1
1
0
1.4
83.3
hippocampal volume
1
1
0
7.2
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
96
intelligence
3
7.2
95.7
cortical surface area measurement
0
9.3
85.2
0
1.4
83.3
hippocampal volume
0
7.2
71.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 4
VGNC:366
459689
Macaque
dipeptidyl peptidase 4
654491
Mouse
MGI:94919
13482
Rat
RGD:2515
25253
Dog
dipeptidyl peptidase 4
VGNC:40074
478767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 4
Macaque
dipeptidyl peptidase 4
Mouse
Rat
Dog
dipeptidyl peptidase 4
Protein Structure (100 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P27487-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 100
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Reactome
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Gene Ontology Terms (36)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (177)
1 – 10 of 177
GCG
Tchem
Novelty: 0.00004879
Score: 0.994
Data Source: Reactome,STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.993
Data Source: Reactome,STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.942
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.942
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
Score: 0.928
Data Source: STRINGDB
ADA
Tclin
Family: Enzyme
Novelty: 0.00072339
Score: 0.918
Data Source: STRINGDB
GLP1R
Tclin
Family: GPCR
Novelty: 0.0006899
Score: 0.899
Data Source: STRINGDB
PRCP
Tchem
Family: Enzyme
Novelty: 0.00697844
Score: 0.892
Data Source: STRINGDB
SLC5A2
Tclin
Family: Transporter
Novelty: 0.00066797
Score: 0.892
Data Source: STRINGDB
SLC5A4
Tchem
Family: Transporter
Novelty: 0.00070175
Score: 0.891
Data Source: STRINGDB
Publication Statistics
PubMed Score  6275.42

PubMed score by year
PubTator Score  3504.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: