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Tclin
DPP4
Dipeptidyl peptidase 4

Protein Summary
Description
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360534
  • ENSP00000353731
  • ENSG00000197635

Symbol
  • ADCP2
  • CD26
  • CD26
  • ADABP
  • ADCP2
  • DPPIV
  • TP103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
drug
1
PubMedID
0.99
cellular component
0.98
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7437.02   (req: < 5)
Gene RIFs: 359   (req: <= 3)
Antibodies: 1632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7437.02   (req: >= 5)
Gene RIFs: 359   (req: > 3)
Antibodies: 1632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3393
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
hesperetin
Rendered image for hesperetin
saxagliptin
Rendered image for saxagliptin
teneligliptin
Rendered image for teneligliptin
anagliptin
Rendered image for anagliptin
vildagliptin
Rendered image for vildagliptin
linagliptin
Rendered image for linagliptin
sitagliptin
Rendered image for sitagliptin
alogliptin
Rendered image for alogliptin
gemigliptin
Rendered image for gemigliptin
trelagliptin
Rendered image for trelagliptin
Protein-Protein Interactions (177)
GCG
Tchem
Novelty:  0.00004879
Score:  0.994
Data Source:  Reactome,STRINGDB
GIP
Tbio
Novelty:  0.0007219
Score:  0.993
Data Source:  Reactome,STRINGDB
ACE2
Tchem
Family:  Enzyme
Novelty:  0.00028408
Score:  0.942
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.942
Data Source:  STRINGDB
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
Score:  0.928
Data Source:  STRINGDB
ADA
Tclin
Family:  Enzyme
Novelty:  0.00072339
Score:  0.918
Data Source:  STRINGDB
GLP1R
Tclin
Family:  GPCR
Novelty:  0.0006899
Score:  0.899
Data Source:  STRINGDB
PRCP
Tchem
Family:  Enzyme
Novelty:  0.00697844
Score:  0.892
Data Source:  STRINGDB
SLC5A2
Tclin
Family:  Transporter
Novelty:  0.00066797
Score:  0.892
Data Source:  STRINGDB
SLC5A4
Tchem
Family:  Transporter
Novelty:  0.00070175
Score:  0.891
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Reactome
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
4
4
6.5
96.9
cortical surface area measurement
2
4
0
9.3
96
intelligence
5
7
5
6.9
94.2
mathematical ability
4
3
6
91.7
cognitive function measurement
3
3
4
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
6.5
96.9
cortical surface area measurement
0
9.3
96
intelligence
5
6.9
94.2
mathematical ability
6
91.7
cognitive function measurement
4
91.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 4
VGNC:366
459689
Macaque
dipeptidyl peptidase 4
654491
Mouse
MGI:94919
13482
Rat
RGD:2515
25253
Dog
dipeptidyl peptidase 4
VGNC:40074
478767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 4
Macaque
dipeptidyl peptidase 4
Mouse
Rat
Dog
dipeptidyl peptidase 4
Publication Statistics
PubMed Score 7437.02
PubMed score by year
PubTator Score 3504.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title