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Tbio
CALML3
Calmodulin-like protein 3

Protein Summary
Description
May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315238
  • ENSP00000315299
  • ENSG00000178363

Symbol
  • CLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.57
gene perturbation
0.57
pathway
0.56
cell type or tissue
0.55
protein complex
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.75   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.75   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (231)
UNC13B
Tbio
Novelty:  0.00429808
p_int:  0.999999927
p_ni:  7.2e-8
Score:  0.321
Data Source:  BioPlex,STRINGDB
JOSD1
Tbio
Novelty:  0.20367997
p_int:  0.99999973
p_ni:  1.31e-7
p_wrong:  1.39e-7
Data Source:  BioPlex
KIAA1551
Tdark
Novelty:  0.25602289
p_int:  0.999997829
p_ni:  0.000002171
Data Source:  BioPlex
UBE3B
Tbio
Family:  Enzyme
Novelty:  0.06274049
p_int:  0.999996917
p_ni:  0.000003083
Data Source:  BioPlex
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
p_int:  0.999983728
p_ni:  0.000016272
Data Source:  BioPlex
SUGP1
Tbio
Novelty:  0.00434166
p_int:  0.999958669
p_ni:  0.000041323
p_wrong:  8e-9
Data Source:  BioPlex
TCEAL8
Tdark
Novelty:  1.0765394
p_int:  0.999921479
p_ni:  0.000009699
p_wrong:  0.000068822
Data Source:  BioPlex
KDM3B
Tbio
Family:  Epigenetic
Novelty:  0.05322289
p_int:  0.999908024
p_ni:  0.000091956
p_wrong:  2e-8
Data Source:  BioPlex
IK
Tbio
Novelty:  0.01510642
p_int:  0.999892364
p_ni:  0.000107636
Data Source:  BioPlex
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.999859557
p_ni:  0.000140443
Data Source:  BioPlex
Nearest Tclin Targets (23)
Explore Nearest Tclin Targets
Pathways (43)
Find Similar Targets
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Inflammatory mediator regulation of TRP channels
KEGG
Aldosterone synthesis and secretion
KEGG
Oxytocin signaling pathway
KEGG
Kaposi sarcoma-associated herpesvirus infection
KEGG
Gastric acid secretion
Name
Explore in Pharos
Explore in Source
Inflammatory mediator regulation of TRP channels
Aldosterone synthesis and secretion
Oxytocin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Gastric acid secretion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
36.5
heel bone mineral density
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
36.5
heel bone mineral density
1
8.5
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 29.75
PubMed score by year
PubTator Score 485.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title