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Tbio
ATP6V0C
V-type proton ATPase 16 kDa proteolipid subunit

Protein Summary
Description
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330398
  • ENSP00000329757
  • ENSG00000185883

Symbol
  • ATP6C
  • ATP6L
  • ATPL
  • ATPL
  • VATL
  • VPPC
  • Vma3
  • ATP6C
  • ATP6L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
molecular function
0.97
transcription factor perturbation
0.97
cellular component
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.69   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.69   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
35
BMI-adjusted hip circumference
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
35
BMI-adjusted hip circumference
1
14.2
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit c
VGNC:9002
453837
Mouse
MGI:88116
11984
Rat
RGD:621394
170667
Dog
ATPase H+ transporting V0 subunit c
VGNC:38272
479877
Horse
ATPase H+ transporting V0 subunit c
VGNC:15671
100065783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit c
Mouse
Rat
Dog
ATPase H+ transporting V0 subunit c
Horse
ATPase H+ transporting V0 subunit c
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P27449-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (245)
1 – 10 of 245
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999855128
p_ni:  0.000144872
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.999721363
p_ni:  0.000278637
Score:  0.997
Data Source:  BioPlex,STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
p_int:  0.999339925
p_ni:  0.000660059
p_wrong:  1.7e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.998617099
p_ni:  0.001382798
p_wrong:  1.04e-7
Score:  0.831
Data Source:  BioPlex,STRINGDB
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
p_int:  0.997894772
p_ni:  0.002105004
p_wrong:  2.24e-7
Score:  0.863
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.996005016
p_ni:  0.003994979
p_wrong:  5e-9
Score:  0.939
Data Source:  BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.995532306
p_ni:  0.004467694
Score:  0.993
Data Source:  BioPlex,STRINGDB
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.99245456
p_ni:  0.007545358
p_wrong:  8.1e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.989949118
p_ni:  0.010049798
p_wrong:  0.000001084
Data Source:  BioPlex
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.939573725
p_ni:  0.060426275
Score:  0.877
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  91.69

PubMed score by year
PubTator Score  20.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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