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Tchem
MARK3
MAP/microtubule affinity-regulating kinase 3

Protein Summary
Description
Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216288
  • ENSP00000216288
  • ENSG00000075413
  • ENST00000303622
  • ENSP00000303698
  • ENST00000416682
  • ENSP00000408092
  • ENST00000429436
  • ENSP00000411397
  • ENST00000440884
  • ENSP00000402104
  • ENST00000553942
  • ENSP00000450772

Symbol
  • CTAK1
  • EMK2
  • KP78
  • VIPB
  • CTAK1
  • PAR1A
  • Par-1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
disease perturbation
0.98
protein domain
0.97
interacting protein
0.93
molecular function
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.96   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 418   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.96   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
midostaurin
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
7
97.8
femoral neck bone mineral density
1
1
1
74.3
3
3
2
1
70.9
systolic blood pressure
1
1
1
61.7
appendicular lean mass
1
1
1
52.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
7
97.8
femoral neck bone mineral density
1
74.3
2
1
70.9
systolic blood pressure
1
61.7
appendicular lean mass
1
52.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Protein-Protein Interactions (127)
1 – 10 of 127
COL4A3BP
Tbio
Novelty: 0.00357203
p_int: 0.999999895
p_ni: 1.05e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
PIM1
Tchem
Family: Kinase
Novelty: 0.0049837
p_int: 0.999988439
p_ni: 0.000011561
Score: 0.636
Data Source: BioPlex,STRINGDB
NRROS
Tbio
Novelty: 0.08976002
p_int: 0.999974347
p_ni: 0.000025653
Score: 0.185
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.999781015
p_ni: 0.000218956
p_wrong: 3e-8
Data Source: BioPlex
CASQ2
Tbio
Novelty: 0.00775794
p_int: 0.999768207
p_ni: 0.000231792
Data Source: BioPlex
TMCC2
Tdark
Novelty: 0.21581357
p_int: 0.999738921
p_ni: 0.000261079
Score: 0.19
Data Source: BioPlex,STRINGDB
NUAK2
Tchem
Family: Kinase
Novelty: 0.02463599
p_int: 0.999118004
p_ni: 0.000881995
Score: 0.304
Data Source: BioPlex,STRINGDB
MACC1
Tbio
Novelty: 0.00737376
p_int: 0.996511522
p_ni: 0.003488464
p_wrong: 1.4e-8
Data Source: BioPlex
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.995286911
p_ni: 0.004712593
p_wrong: 4.96e-7
Data Source: BioPlex
CDH19
Tbio
Novelty: 0.0759041
p_int: 0.987938309
p_ni: 0.01206169
p_wrong: 1e-9
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.96

PubMed score by year
PubTator Score  271.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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