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Tbio
GIF
Gastric intrinsic factor

Protein Summary
Description
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257248
  • ENSP00000257248
  • ENSG00000134812

Symbol
  • IFMH
  • IF
  • GIF
  • INF
  • IFMH
  • TCN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
cellular component
0.68
pathway
0.58
small molecule perturbation
0.52
cell line
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.66   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.66   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gastric intrinsic factor
VGNC:3270
451215
Mouse
MGI:1202394
14603
Rat
RGD:62084
29319
Dog
gastric intrinsic factor
VGNC:41212
449477
Horse
gastric intrinsic factor
VGNC:18338
100060988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gastric intrinsic factor
Mouse
Rat
Dog
gastric intrinsic factor
Horse
gastric intrinsic factor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P27352-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (50)
1 – 10 of 50
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.975502876
p_ni: 0.024495792
p_wrong: 0.000001332
Score: 0.214
Data Source: BioPlex,STRINGDB
GALNT5
Tbio
Family: Enzyme
Novelty: 0.17644497
p_int: 0.845733285
p_ni: 0.154266715
Score: 0.692
Data Source: BioPlex,STRINGDB
CUBN
Tbio
Novelty: 0.00441944
Score: 0.997
Data Source: Reactome,STRINGDB
AMN
Tbio
Novelty: 0.030358
Score: 0.978
Data Source: Reactome,STRINGDB
TCN1
Tbio
Novelty: 0.00305315
Score: 0.919
Data Source: STRINGDB
PRSS1
Tclin
Family: Enzyme
Novelty: 0.00157396
Score: 0.9
Data Source: STRINGDB
GAST
Tbio
Novelty: 0.00011795
Score: 0.708
Data Source: STRINGDB
CD320
Tbio
Novelty: 0.01978884
Score: 0.64
Data Source: STRINGDB
MTR
Tbio
Family: Enzyme
Novelty: 0.0006987
Score: 0.634
Data Source: STRINGDB
C1R
Tclin
Novelty: 0.00210654
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  186.66

PubMed score by year
PubTator Score  554.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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