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Tchem
YWHAQ
14-3-3 protein theta

Protein Classes
Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238081
  • ENSP00000238081
  • ENSG00000134308
  • ENST00000381844
  • ENSP00000371267

Symbol
  • 1C5
  • HS1
  • 14-3-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.24   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 527   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.24   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 527   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3814675
chemical structure image
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (78)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (260)
1 – 10 of 260
FAM86C1
Tdark
Family: Enzyme
Novelty: 1.61781609
p_int: 0.997242872
p_ni: 0.002757128
Data Source: BioPlex
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.989617098
p_ni: 0.010382902
Data Source: BioPlex
SMTNL2
Tdark
Novelty: 0.33805653
p_int: 0.98494734
p_ni: 0.01505266
Score: 0.643
Data Source: BioPlex,STRINGDB
KIAA0930
Tbio
Novelty: 0.16492958
p_int: 0.980815669
p_ni: 0.019184331
Score: 0.813
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.97931583
p_ni: 0.02068417
Score: 0.366
Data Source: BioPlex,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.961954514
p_ni: 0.038045486
Score: 0.972
Data Source: BioPlex,STRINGDB
SIPA1L3
Tbio
Novelty: 0.13962558
p_int: 0.946775709
p_ni: 0.053224291
Score: 0.231
Data Source: BioPlex,STRINGDB
EPB41L1
Tbio
Novelty: 0.02937451
p_int: 0.932490903
p_ni: 0.067509097
Score: 0.366
Data Source: BioPlex,STRINGDB
SPATA13
Tbio
Novelty: 0.19610601
p_int: 0.920045606
p_ni: 0.079954394
Score: 0.418
Data Source: BioPlex,STRINGDB
LNP1
Tdark
Novelty: 0.00457285
p_int: 0.918617143
p_ni: 0.081382857
Data Source: BioPlex
Publication Statistics
PubMed Score  331.24

PubMed score by year
PubTator Score  30.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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