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Tclin
MAOB
Amine oxidase [flavin-containing] B

Protein Summary
Description
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378069
  • ENSP00000367309
  • ENSG00000069535
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.87
biological term
0.8
chemical
0.8
cellular component
0.79


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3305.94   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3305.94   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1078
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase B
VGNC:1362
465588
Macaque
monoamine oxidase B
708468
Mouse
MGI:96916
109731
Rat
RGD:3041
25750
Dog
monoamine oxidase B
VGNC:42954
403451
Species
Name
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase B
Macaque
monoamine oxidase B
Mouse
Rat
Dog
monoamine oxidase B
Protein Structure (44 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P27338-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 44
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Amine Oxidase reactions (R-HSA-140179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine Oxidase reactions
Reactome
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Amine Oxidase reactions
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Protein-Protein Interactions (127)
1 – 10 of 127
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.999999943
p_ni: 5.6e-8
p_wrong: 1e-9
Score: 0.242
Data Source: BioPlex,STRINGDB
CD226
Tbio
Novelty: 0.00374102
p_int: 0.999999857
p_ni: 2.4e-8
p_wrong: 1.19e-7
Data Source: BioPlex
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
p_int: 0.999999666
p_ni: 3.2e-7
p_wrong: 1.3e-8
Score: 0.945
Data Source: BioPlex,STRINGDB
COMT
Tclin
Family: Enzyme
Novelty: 0.00025107
Score: 0.986
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.981
Data Source: STRINGDB
DBH
Tchem
Family: Enzyme
Novelty: 0.00074741
Score: 0.951
Data Source: STRINGDB
AOC2
Tchem
Family: Enzyme
Novelty: 0.0048282
Score: 0.948
Data Source: STRINGDB
PNMT
Tchem
Family: Enzyme
Novelty: 0.00178141
Score: 0.946
Data Source: STRINGDB
CYP2D6
Tclin
Family: Enzyme
Novelty: 0.00021853
Score: 0.946
Data Source: STRINGDB
AOC3
Tchem
Family: Enzyme
Novelty: 0.00078739
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  3305.94

PubMed score by year
PubTator Score  1809.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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