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Tclin
MAOB
Amine oxidase [flavin-containing] B

Protein Summary
Description
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378069
  • ENSP00000367309
  • ENSG00000069535
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.87
biological term
0.8
chemical
0.8
cellular component
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3372.75   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3372.75   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1526
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (15)
phenelzine
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rosiglitazone
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pioglitazone
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istradefylline
Rendered image for istradefylline
menadione
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tranylcypromine
Rendered image for tranylcypromine
rasagiline
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isocarboxazid
Rendered image for isocarboxazid
moclobemide
Rendered image for moclobemide
pargyline
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Protein-Protein Interactions (127)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999999943
p_ni:  5.6e-8
p_wrong:  1e-9
Score:  0.242
Data Source:  BioPlex,STRINGDB
CD226
Tbio
Novelty:  0.00374102
p_int:  0.999999857
p_ni:  2.4e-8
p_wrong:  1.19e-7
Data Source:  BioPlex
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
p_int:  0.999999666
p_ni:  3.2e-7
p_wrong:  1.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.986
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.981
Data Source:  STRINGDB
DBH
Tchem
Family:  Enzyme
Novelty:  0.00074741
Score:  0.951
Data Source:  STRINGDB
AOC2
Tchem
Family:  Enzyme
Novelty:  0.0048282
Score:  0.948
Data Source:  STRINGDB
PNMT
Tchem
Family:  Enzyme
Novelty:  0.00178141
Score:  0.946
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.946
Data Source:  STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Amine Oxidase reactions (R-HSA-140179)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine Oxidase reactions
Reactome
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Amine Oxidase reactions
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
4
44.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
44.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase B
VGNC:1362
465588
Macaque
monoamine oxidase B
708468
Mouse
MGI:96916
109731
Rat
RGD:3041
25750
Dog
monoamine oxidase B
VGNC:42954
403451
Species
Name
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase B
Macaque
monoamine oxidase B
Mouse
Rat
Dog
monoamine oxidase B
Publication Statistics
PubMed Score 3372.75
PubMed score by year
PubTator Score 1809.50
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title